Study of Brain Activity Using Optical Pumping Magnetometer Magnetoencephalography in Healthy Adults, Newborns, Premature Babies, and Pregnant Women

What this Trial Is About

Researchers are studying the use of Magnetoencephalography MEG with Optical Pumping Magnetometer OPM sensors to record brain activity in healthy adults, premature and full-term newborns, and pregnant women. This study aims to identify brain development biomarkers using MEG, which offers better time and spatial resolution than traditional EEG. The project focuses on comparing MEG with OPM sensors to high-resolution EEG, as OPM sensors do not require costly helium cooling like traditional SQUID sensors. Participants will undergo 40 minutes of MEG using the OPM technology. The study includes four groups healthy adults aged 18 to 65, full-term newborns aged 38 to 42 weeks gestational age, premature newborns aged 28 to 36 weeks gestational age, and pregnant women between 28 and 40 weeks gestational age. This non-randomized study is single-masked and does not involve a placebo or comparison drug. During the study, researchers will measure the signal-to-noise ratio of MEG with OPM sensors and compare it to that of high-resolution EEG. Participants will be evaluated on a single day, with the primary outcomes focused on brain activity signal quality. Safety is monitored by excluding participants with devices that cause interference and those unable to remain still. The study will continue until April 2026, and participants will be involved in a short, focused session to assess brain activity.

Magnetoencephalography by Optical Pumping Magnetometer