Study of High-resolution Manometry With Impedancemetry to Assess Esophageal Clearance in Adults Treated for Achalasia by POEM

What this Trial Is About

Researchers are investigating esophageal clearance in patients with achalasia who have been treated using POEM Peroral Endoscopic Myotomy. The study aims to compare two methods of assessing esophageal clearance high-resolution manometry with impedancemetry HRiM and timed barium esophagogram TBE. This comparison may help determine if HRiM can replace TBE, which involves radiation exposure. The study also evaluates treatment outcomes using the Eckardt score, a clinical symptom score, and quality of life assessments. Patients treated with POEM undergo assessments before and after treatment, including the Eckardt score, TBE, and HRiM. Treatment failure is identified by an Eckardt score above 3 at three months after POEM. Incomplete esophageal clearance is defined by specific findings in HRiM or TBE at five minutes. The study observes these measures at three months and follows up with a one-year Eckardt score to understand long-term symptoms. All examinations are part of routine care. Participants will have symptom evaluations, esophageal clearance tests, and quality of life questionnaires at three months and one year after treatment. The study measures esophageal clearance and symptom scores to understand the effectiveness of the assessments. Quality of life is evaluated with several questionnaires. The study is observational and follows patients without altering their routine treatment. Participation lasts at least one year, with data collected during standard medical visits.

MARIMPACH : Contribution of High-resolution Manometry With Impedancemetry for the Evaluation of Esophageal Clearance in Achalasia