Actively Recruiting
Measurement of Airway Opening Index During Out-of-hospital Cardiac Arrest The Lazarus AOI Trial
Led by University Hospital, Ghent · Updated on 2026-02-27
150
Participants Needed
1
Research Sites
13 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Out-of-hospital cardiac arrest (OHCA) is a major cause of death worldwide, and despite advances in resuscitation methods, survival rates remain low. Researchers are studying the Airway Opening Index (AOI), a measure derived from capnogram data that reflects airway closure during cardiopulmonary resuscitation (CPR). This study aims to understand how common airway closure is during CPR, whether AOI relates to the return of spontaneous circulation (ROSC), and if positive end-expiratory pressure (PEEP) affects these outcomes. This research is a retrospective observational cohort study analyzing capnogram data from about 150 OHCA cases recorded in the Lazarus database. The study compares groups of patients who achieved ROSC during initial resuscitation with those who did not. The AOI will be calculated using a mathematical model based on previous research. The study also examines whether PEEP influences AOI and ROSC. Participants are adults over 18 years who experienced OHCA, underwent CPR, and were intubated with capnogram data available immediately after intubation. Data collected includes capnogram waveforms and patient information such as age, gender, and arrest circumstances. The primary outcome measured is ROSC during initial resuscitation. The study will analyze the relationship between AOI and ROSC while adjusting for confounding factors to improve understanding of airway dynamics during CPR.
CONDITIONS
Brief Title
Measurement of Airway Opening Index During Out-of-hospital Cardiac Arrest: The Lazarus AOI Trial.
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adult (over 18 years old) patients with out-of-hospital cardiac arrest
- Patients undergoing cardiopulmonary resuscitation (CPR)
- Patients who were intubated and had available capnogram recordings immediately after intubation
You will not qualify if you...
- Patients that were not intubated
- Patients that did not receive CPR following intubation
- Cases with technical challenges affecting the ETCO2 measurement or capnogram waveform data
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
Duration - Retrospective data collection
Participants' capnography data from out-of-hospital cardiac arrest cases are analyzed retrospectively.
Duration - Up to study completion date
Participants are observed based on collected data to assess airway opening and resuscitation outcomes.
Trial Site Locations
Total: 1 location
1
Ghent University Hospital
Ghent, East-Flanders, Belgium, B9000
Actively Recruiting
Research Team
S
Said Hachimi Idrissi, MD, PhD
T
Thomas Tackaert, MD
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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