Study of Airway Opening Index During CPR in Adults With Out-of-Hospital Cardiac Arrest

What this Trial Is About

Out-of-hospital cardiac arrest OHCA is a major cause of death worldwide, and despite advances in resuscitation methods, survival rates remain low. Researchers are studying the Airway Opening Index AOI, a measure derived from capnogram data that reflects airway closure during cardiopulmonary resuscitation CPR. This study aims to understand how common airway closure is during CPR, whether AOI relates to the return of spontaneous circulation ROSC, and if positive end-expiratory pressure PEEP affects these outcomes. This research is a retrospective observational cohort study analyzing capnogram data from about 150 OHCA cases recorded in the Lazarus database. The study compares groups of patients who achieved ROSC during initial resuscitation with those who did not. The AOI will be calculated using a mathematical model based on previous research. The study also examines whether PEEP influences AOI and ROSC. Participants are adults over 18 years who experienced OHCA, underwent CPR, and were intubated with capnogram data available immediately after intubation. Data collected includes capnogram waveforms and patient information such as age, gender, and arrest circumstances. The primary outcome measured is ROSC during initial resuscitation. The study will analyze the relationship between AOI and ROSC while adjusting for confounding factors to improve understanding of airway dynamics during CPR.

Measurement of Airway Opening Index During Out-of-hospital Cardiac Arrest: The Lazarus AOI Trial.