A Dutch nationwide pediatric cardiac arrest registry with long-term follow-up - towards an international prognostication guideline.
Marijn Albrecht, Maayke Hunfeld, Annemieke Arkesteijn-Muit...
https://pubmed.ncbi.nlm.nih.gov/40491775Actively Recruiting
Age: 24Hours - 18Years
All Genders
ID06938009
Pediatric Resuscitation Neuroprognostication and Outcomes Registry Observational Study of Pediatric Cardiac Arrest in the Netherlands
Led by Matthijs de Hoog · Updated on 2025-04-22
500
Participants Needed
7
Research Sites
N/A
Total Duration
On this page
Sponsors
M
Matthijs de Hoog
Lead Sponsor
A
Amsterdam UMC
Collaborating Sponsor
AI-Summary
What this Trial Is About
This research aims to better understand the long-term outcomes of children in the Netherlands who experience cardiac arrest, whether in or out of the hospital. The study focuses on survival rates, neurological outcomes, emergency care, and how children and their families adjust over time after the event. It is an observational registry collecting data from routine medical care without additional interventions. The study includes children under 18 years old who have had a cardiac arrest and were treated by emergency services or admitted to one of seven academic pediatric hospitals. Cardiac arrest is defined as no pulse or the need for chest compressions lasting at least one minute. Data are gathered from medical records and follow-up visits at 3, 12, and 24 months after arrest, and at ages 5, 8, 12, and 17 years depending on the child’s age at arrest. Participants' routine care data are collected anonymously, and survivors are invited for follow-up assessments that include physical, neurological, and psychological evaluations using standardized tools. Researchers monitor long-term neurological outcomes and family functioning through outpatient visits, ensuring data quality through audits and validation. The study will continue collecting data over many years to explore recovery patterns and outcomes.
CONDITIONS
Brief Title
Dutch Registry of Pediatric Cardiac Arrest
Who Can Participate
Age: 24Hours - 18Years
All Genders
Eligibility Criteria
You may qualify if you...
- Pediatric patients under the age of 18
- Experienced in-hospital or out-of-hospital cardiac arrest in the Netherlands
- Attended by emergency medical services or admitted to one of the seven participating Dutch academic pediatric hospitals
- Cardiac arrest defined as absence of palpable pulse or need for chest compressions lasting 651 minute
- Arrest managed under European Resuscitation Council guidelines (BLS/APLS)
You will not qualify if you...
- Cardiac arrest occurring in neonates younger than 24 hours of age
- Cardiac arrest occurring in a neonatal intensive care unit (NICU) setting
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
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Your Study Journey
Screening
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
Screening and enrollment occur as part of routine emergency and hospital care.
Monitoring
Duration - Initial hospital admission period (days to weeks)
Participants who experience pediatric cardiac arrest are observed through data collected during routine emergency response, hospital admission, and inpatient care to evaluate diagnostic practices, interventions, and short-term outcomes.
Data collected continuously during emergency medical response and inpatient hospital stay without additional study visits.
Long-term Monitoring
Duration - Up to 17 years depending on participant age at cardiac arrest
Participants are followed up during routine outpatient visits to assess long-term neurological and neuropsychological outcomes after cardiac arrest.
Outpatient follow-up visits at approximately 3, 12, and 24 months post-arrest, and at ages 5, 8, 12, and 17 years depending on age at event.
Trial Site Locations
Total: 7 locations
1
Radboud umc
Nijmegen, Gelderland, Netherlands, 6525 XZ
Actively Recruiting
2
MUMC
Maastricht, Limburg, Netherlands, 6229 ET
Actively Recruiting
3
Amsterdam UMC
Amsterdam, North Holland, Netherlands, 1105 AZ
Actively Recruiting
4
UMCG
Groningen, Provincie Groningen, Netherlands, 9713 GZ
Actively Recruiting
5
LUMC
Leiden, South Holland, Netherlands, 2333 ZG
Actively Recruiting
6
Erasmus MC
Rotterdam, South Holland, Netherlands, 3015GD
Actively Recruiting
7
UMCU
Utrecht, Utrecht, Netherlands, 3584 CX
Actively Recruiting
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Research Team
G
Gabry De Jong
M
Marijn Albrecht, MD
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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