Usefulness of FFR-CT to exclude haemodynamically significant lesions in high-risk NSTE-ACS.
David Meier, Daniele Andreini, Bernard Cosyns...
https://pubmed.ncbi.nlm.nih.gov/39468963Actively Recruiting
Led by Universitair Ziekenhuis Brussel · Updated on 2026-02-05
30
Participants Needed
1
Research Sites
13 weeks
Total Duration
Researchers are evaluating a new CT scan technique called ECG-less gated cardiac CT to see if it can accurately assess the coronary arteries in patients who survive a cardiac arrest without showing clear signs of a specific type of heart attack known as STEMI. This is important because current tests sometimes cannot clearly identify the cause of cardiac arrest, and the standard coronary angiography, while effective, is more invasive and carries some risks. The study aims to improve how doctors select patients who need urgent coronary angiography. The study uses an innovative CT scan method that does not require attaching ECG leads or extra medication, making it faster and safer in emergency settings. Patients undergo a combined pulmonary CT angiography and ECG-less cardiac scan using specialized equipment. This new technique captures images of the heart and blood vessels without additional contrast or drug administration, and the results will be compared to those from conventional coronary angiography. Participants are cardiac arrest survivors without STEMI who undergo the CT scan and then have a coronary angiography within 24 hours. Researchers will compare the two imaging results to measure how accurately the new CT technique identifies coronary artery disease. Additional follow-up evaluations include survival and heart function assessments up to 90 days after enrollment. The study involves various clinical measurements, monitoring, and safety evaluations throughout the process.
CONDITIONS
Diagnostic Accuracy of ECG-less Gated Cardiac CT in Resuscitated Cardiac Arrest Survivors Without ST Elevation Myocardial Infarction
You may qualify if you...
You will not qualify if you...
Complete this quick 3-step screening to check your eligibility
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Within 24 hours after screening and enrollment
Participants undergo an ECG-less gated cardiac CT scan combined with pulmonary CT angiography to assess for coronary artery disease and other causes of cardiac arrest without the need for an ECG signal or additional contrast injection.
1 visit (in-person)
Duration - 90 days
Participants are monitored for survival, neurologic status, cardiac function, and other health outcomes related to cardiac arrest for up to 90 days after the CT scan.
Follow-up visits as needed over 90 days
Total: 1 location
1
Universitair Ziekenhuis Brussel (UZB)
Brussels, Vlaams Brabant, Belgium, 1090
Actively Recruiting
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
DIAGNOSTIC
Number of Arms
1
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