Actively Recruiting

Phase Not Applicable
Age: 18Years +
All Genders
ID07388342

Diagnostic Accuracy of ECG-less Gated Cardiac CT in Resuscitated Cardiac Arrest Survivors

Led by Universitair Ziekenhuis Brussel · Updated on 2026-02-05

30

Participants Needed

1

Research Sites

13 weeks

Total Duration

On this page

AI-Summary

What this Trial Is About

Researchers are evaluating a new CT scan technique called ECG-less gated cardiac CT to see if it can accurately assess the coronary arteries in patients who survive a cardiac arrest without showing clear signs of a specific type of heart attack known as STEMI. This is important because current tests sometimes cannot clearly identify the cause of cardiac arrest, and the standard coronary angiography, while effective, is more invasive and carries some risks. The study aims to improve how doctors select patients who need urgent coronary angiography. The study uses an innovative CT scan method that does not require attaching ECG leads or extra medication, making it faster and safer in emergency settings. Patients undergo a combined pulmonary CT angiography and ECG-less cardiac scan using specialized equipment. This new technique captures images of the heart and blood vessels without additional contrast or drug administration, and the results will be compared to those from conventional coronary angiography. Participants are cardiac arrest survivors without STEMI who undergo the CT scan and then have a coronary angiography within 24 hours. Researchers will compare the two imaging results to measure how accurately the new CT technique identifies coronary artery disease. Additional follow-up evaluations include survival and heart function assessments up to 90 days after enrollment. The study involves various clinical measurements, monitoring, and safety evaluations throughout the process.

CONDITIONS

Brief Title

Diagnostic Accuracy of ECG-less Gated Cardiac CT in Resuscitated Cardiac Arrest Survivors Without ST Elevation Myocardial Infarction

Who Can Participate

Age: 18Years +
All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • Adults (≥18 years) with sustained return of spontaneous circulation (ROSC) after in- or out-of-hospital cardiac arrest
  • Informed consent obtained from patient or representative before invasive coronary angiography
Not Eligible

You will not qualify if you...

  • Patients on VA-ECMO
  • Presence of ACS STEMI or STEMI equivalent (new bundle branch block, specific ECG changes indicating myocardial infarction)
  • ACS NSTEMI with ongoing ischemia requiring urgent invasive coronary angiography
  • Hemodynamic or electrical instability preventing CT imaging
  • Life-threatening arrhythmia possibly caused by acute myocardial ischemia
  • Absolute contraindications to iodinated contrast
  • Known non-cardiac cause of cardiac arrest where chest CT is not required
  • Known or likely pregnancy or lactation
  • Severe bleeding issues preventing heparin use during coronary angiography
  • Prior coronary intervention (stent or bypass surgery)
  • CT findings that preclude short-term coronary angiography
  • Patients on end-of-life care pathways
  • Participation in another intervention study interfering with this research

AI-Screening

AI-Powered Screening

Complete this quick 3-step screening to check your eligibility

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Your Study Journey

Screening

Duration - 2 to 4 weeks

Participants are screened for eligibility to participate in the trial.

1 visit (in-person)

Implementation

Duration - Within 24 hours after screening and enrollment

Participants undergo an ECG-less gated cardiac CT scan combined with pulmonary CT angiography to assess for coronary artery disease and other causes of cardiac arrest without the need for an ECG signal or additional contrast injection.

1 visit (in-person)

Monitoring

Duration - 90 days

Participants are monitored for survival, neurologic status, cardiac function, and other health outcomes related to cardiac arrest for up to 90 days after the CT scan.

Follow-up visits as needed over 90 days

Trial Site Locations

Total: 1 location

1

Universitair Ziekenhuis Brussel (UZB)

Brussels, Vlaams Brabant, Belgium, 1090

Actively Recruiting

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How is the study designed?

Study Type

INTERVENTIONAL

Masking

NONE

Allocation

NA

Model

SINGLE_GROUP

Primary Purpose

DIAGNOSTIC

Number of Arms

1

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Published Research Related To This Trial

Diagnostic accuracy of 64-slice computed tomography coronary angiography: a prospective, multicenter, multivendor study.

W Bob Meijboom, Matthijs F L Meijs, Joanne D Schuijf...

https://pubmed.ncbi.nlm.nih.gov/19095130

Diagnostic performance of 64-multidetector row coronary computed tomographic angiography for evaluation of coronary artery stenosis in individuals without known coronary artery disease: results from the prospective multicenter ACCURACY (Assessment by Coronary Computed Tomographic Angiography of Individuals Undergoing Invasive Coronary Angiography) trial.

Matthew J Budoff, David Dowe, James G Jollis...

https://pubmed.ncbi.nlm.nih.gov/19007693

Role of cardiac troponin in the diagnosis of acute myocardial infarction in comatose patients resuscitated from out-of-hospital cardiac arrest.

Sebastian Voicu, Georgios Sideris, Nicolas Deye...

https://pubmed.ncbi.nlm.nih.gov/22037386

Post-Resuscitation ECG for Selection of Patients for Immediate Coronary Angiography in Out-of-Hospital Cardiac Arrest.

Henrik Stær-Jensen, Espen Rostrup Nakstad, Eigil Fossum...

https://pubmed.ncbi.nlm.nih.gov/26453688

Value of post-resuscitation electrocardiogram in the diagnosis of acute myocardial infarction in out-of-hospital cardiac arrest patients.

Georgios Sideris, Sebastian Voicu, Jean Guillaume Dillinger...

https://pubmed.ncbi.nlm.nih.gov/21632166

Combined ECG, Echocardiographic, and Biomarker Criteria for Diagnosing Acute Myocardial Infarction in Out-of-Hospital Cardiac Arrest Patients.

Sang-Eun Lee, Jae-Sun Uhm, Jong-Youn Kim...

https://pubmed.ncbi.nlm.nih.gov/26069108

Can early cardiac troponin I measurement help to predict recent coronary occlusion in out-of-hospital cardiac arrest survivors?

Florence Dumas, Stephane Manzo-Silberman, Jérôme Fichet...

https://pubmed.ncbi.nlm.nih.gov/22488008