Study of Brain and Heart Injury Mechanisms in Adults with Intracranial Hemorrhage Using Multimodal Omics and Imaging

What this Trial Is About

Researchers are investigating the mechanisms behind brain and heart injuries in patients who suffer from intracranial hemorrhage, a serious condition with high death rates and poor recovery outcomes. This condition causes direct brain damage and secondary problems like delayed cerebral ischemia, brain swelling, and fluid buildup. It can also lead to cardiac issues classified as cerebrocardiac syndrome, which includes heart attacks, abnormal heart rhythms, and heart dysfunction, all linked to worse patient outcomes. The exact causes of these brain and heart injuries remain unclear, and this study aims to explore these processes to improve diagnosis and treatment. Participants with intracranial hemorrhage will receive usual care alongside detailed multidisciplinary assessments involving blood and cerebrospinal fluid tests, electrocardiograms, ultrasounds, and imaging scans. The study is observational and uses a combined approach of advanced omics and imaging methods to examine both local brain and systemic injuries. This approach seeks to enhance precise diagnosis, risk evaluation, and clinical decision-making. During the study, researchers will monitor short- and long-term cardiac events, delayed cerebral ischemia, and brain-heart syndrome up to three months after discharge. Functional outcomes will be assessed using the modified Rankin Scale at discharge and three months later. Participants will be evaluated within five days of admission and followed up at three months to collect comprehensive data on their brain and heart health, helping to understand the injury mechanisms and patient recovery over time.

Mechanisms of Brain-Heart Injury of Post-Intracranial Hemorrhage