Study of Inflammatory Cell Mechanisms in Diabetic and Non-Diabetic Chronic Wound Healing

What this Trial Is About

This research focuses on understanding the impaired wound healing process in people with diabetes by studying inflammatory cells from chronic wounds. It compares these wound-derived cells with normal blood-derived cells to explore the mechanisms behind dysregulated inflammation in diabetic individuals. The study aims to uncover molecular reasons for poor wound healing in diabetes to improve future treatments. Participants include adults aged 21 to 80 with chronic wounds lasting more than four weeks, including both diabetic and non-diabetic individuals. The study involves collecting blood samples and wound material using a VAC sponge, which is normally discarded during standard care. No treatments are given as this is an observational study. During the study, researchers will assess wound healing progress at 16 weeks and check infection status at the start. Participants wound and blood cells will be analyzed to compare inflammation and healing mechanisms. The total duration of participation varies, focusing on biological sample collection and monitoring wound healing over time.

Mechanisms Underlying Impaired Diabetic Wound Healing