Diabetes and its effect on wound healing and patient care.
Maria Mousley
https://pubmed.ncbi.nlm.nih.gov/14618996Actively Recruiting
Age: 21Years - 80Years
All Genders
ID00777712
Mechanisms Underlying Impaired Wound Healing
Led by University of Pittsburgh · Updated on 2026-06-05
250
Participants Needed
2
Research Sites
52 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This research focuses on understanding the impaired wound healing process in people with diabetes by studying inflammatory cells from chronic wounds. It compares these wound-derived cells with normal blood-derived cells to explore the mechanisms behind dysregulated inflammation in diabetic individuals. The study aims to uncover molecular reasons for poor wound healing in diabetes to improve future treatments. Participants include adults aged 21 to 80 with chronic wounds lasting more than four weeks, including both diabetic and non-diabetic individuals. The study involves collecting blood samples and wound material using a VAC sponge, which is normally discarded during standard care. No treatments are given as this is an observational study. During the study, researchers will assess wound healing progress at 16 weeks and check infection status at the start. Participants' wound and blood cells will be analyzed to compare inflammation and healing mechanisms. The total duration of participation varies, focusing on biological sample collection and monitoring wound healing over time.
CONDITIONS
Brief Title
Mechanisms Underlying Impaired Diabetic Wound Healing
Who Can Participate
Age: 21Years - 80Years
All Genders
Eligibility Criteria
You may qualify if you...
- Ages 21-80
- Presence of a chronic wound lasting more than 4 weeks
- Both diabetic and non-diabetic individuals
- Adult surgical wounds
You will not qualify if you...
- Unable to provide consent
- Pregnant women
- Therapeutically immunocompromised individuals
- Individuals considered vulnerable under federal regulations (45 CFR 46 Subparts B, C, and D) or other vulnerable populations
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
1
2
3
Your Study Journey
Screening
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Sample Collection
Duration - Single day
Participants provide blood samples and wound fluid for analysis of wound healing mechanisms.
1 visit (in-person)
Long-term Monitoring
Duration - Up to 16 weeks
Participants’ wound healing progress is observed over time without active intervention.
Periodic visits up to Week 16
Trial Site Locations
Total: 2 locations
1
UPMC Montefiore
Pittsburgh, Pennsylvania, United States, 15219
Actively Recruiting
2
UPMC Presbyterian
Pittsburgh, Pennsylvania, United States, 15219
Actively Recruiting
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Research Team
P
Piya Das Ghatak, PhD, MS
U
Urmila Gnyawali
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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Published Research Related To This Trial
Impediments to wound healing.
W K Stadelmann, A G Digenis, G R Tobin
https://pubmed.ncbi.nlm.nih.gov/9777971Report on the prevalence of skin ulcers in a home health agency population.
M Meehan, L O'Hara, Y M Morrison
https://pubmed.ncbi.nlm.nih.gov/10687558Diagnosis and classification of diabetes mellitus.
American Diabetes Association
https://pubmed.ncbi.nlm.nih.gov/17192378Standards of medical care in diabetes--2007.
American Diabetes Association
https://pubmed.ncbi.nlm.nih.gov/17192377