Actively Recruiting
Metabolic Profiling of Hematopoietic Stem Cells in Clonal Hematopoiesis (CHIP)
Led by Imelda Hospital, Bonheiden · Updated on 2026-03-25
24
Participants Needed
1
Research Sites
463 weeks
Total Duration
On this page
Sponsors
I
Imelda Hospital, Bonheiden
Lead Sponsor
U
Université Catholique de Louvain
Collaborating Sponsor
AI-Summary
What this Trial Is About
Bone marrow samples will be collected from patients undergoing hip arthroplasty surgery. Blood and bone marrow samples will be used for metabolic profiling and analysis of relevant CHIP mutations. Combined single-cell transcriptomics and mutation-specific single-cell genotyping (biotin-PCR using mutation-targeted primers followed by sequencing) will subsequently be performed. The gene expression profile of wildtype and mutant hematopoietic stem cells will be compared, performing both broad gene set enrichment analysis and targeted analysis of metabolic pathways.
CONDITIONS
Official Title
Metabolic Profiling of Hematopoietic Stem Cells in Clonal Hematopoiesis (CHIP)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 65 years and older
You will not qualify if you...
- Known haematological condition such as myelodysplasia, leukemia, or cancer
- Inability to provide written informed consent
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Imelda Hospital
Bonheiden, België, Belgium, 2820
Actively Recruiting
Research Team
M
Michaël R. Laurent, MD PhD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here