Actively Recruiting
Methods for Assessing Nutrition, Inflammation, Kidney Function, Aging, Body Composition, and Hydration Among Older Patients - An Observational Study (MIKADO)
Led by Ove Andersen · Updated on 2026-03-30
500
Participants Needed
1
Research Sites
391 weeks
Total Duration
On this page
Sponsors
O
Ove Andersen
Lead Sponsor
H
Hvidovre University Hospital
Collaborating Sponsor
AI-Summary
What this Trial Is About
Researchers are investigating better ways to assess malnutrition and kidney diseases in older hospitalized patients. This observational study focuses on evaluating modern methods and biomarkers to estimate nutritional status and kidney function, comparing them to current gold standards. The study also explores how factors like body composition, hydration, inflammation, and age influence these assessments. The study involves several groups of older patients, including those acutely admitted aged 65 or older, patients aged 90 and above, patients with BMI of 35 kg/m2 or higher, those receiving prednisolone treatment for COPD exacerbations, and patients undergoing lower leg amputations. The researchers will examine various kidney function estimates using markers like creatinine, cystatin C, B2M, and BTP, comparing them to measured glomerular filtration rates over different time frames depending on patient groups. Participants will be assessed at enrollment and followed up at specific intervals, such as 14 days, 2 weeks, or up to 35 days after treatments or procedures. The study includes evaluations of body composition, hydration status, inflammation, aging biomarkers, and nutritional markers. Data collection involves biomarker panels, body composition measurements, and performance of kidney function tests to understand the impact of these factors on diagnostic accuracy. This research aims to refine assessment methods in older hospitalized patients, with monitoring continuing throughout the hospitalization and treatment periods.
CONDITIONS
Brief Title
Methods for Nutrition, Inflammation, Kidney Function, Aging, Body Composition, and Hydration Among Older Patients
Who Can Participate
Eligibility Criteria
You may qualify if you...
- 65 years or older (groups 1, 4, and 5)
- 90 years or older (group 3)
- Acutely admitted to the hospital (groups 1 and 2)
- Cognitively able to cooperate (group 1)
- Able to read and speak Danish (all groups)
- Body mass index (BMI) of 35 kg/m2 or higher (group 4)
- Receiving prednisolone treatment for COPD exacerbations at 37.5 mg daily or more (group 5)
- Undergoing non-traumatic amputation of lower leg (crus or femur) (group 6)
You will not qualify if you...
- Patients in isolation (all groups)
- Receiving terminal treatment (all groups)
- Suicidal patients (all groups)
- Receiving active immune suppressing treatment (groups 2, 3, 4, 5, and 6)
- Having oedemas (groups 2, 3, 4, 5, and 6)
- Currently in active treatment for cancer (groups 2, 3, 4, 5, and 6)
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Same day assessments and up to 2 weeks after inclusion
Participants undergo assessments including measurements of body composition, kidney function tests, and biomarker evaluations to investigate nutrition, inflammation, hydration, and aging status.
1 baseline visit and 1 follow-up visit approximately 2 weeks later
Duration - Up to 10-35 days or approximately 3 weeks after procedures depending on participant group
Participants are observed and monitored over time to evaluate changes in kidney function and body composition, including during and after specific treatments or procedures such as prednisolone therapy or lower leg amputation.
Additional visits depending on treatment or procedure, typically within 1 month after enrollment
Trial Site Locations
Total: 1 location
1
Hvidovre Hospital
Copenhagen, Denmark
Actively Recruiting
Research Team
O
Ove OA Andersen, Professor
R
Rikke Lundsgaard Nielsen, Phd
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
6
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