Actively Recruiting
Mind After Midnight
Led by University of Arizona · Updated on 2026-02-27
90
Participants Needed
1
Research Sites
182 weeks
Total Duration
On this page
Sponsors
U
University of Arizona
Lead Sponsor
N
National Institute of Mental Health (NIMH)
Collaborating Sponsor
AI-Summary
What this Trial Is About
This study examines whether wakefulness during the biological night (2:00-4:00 AM) is associated with increased negative mood, impaired decision-making, and suicidal thoughts. Adults with a history of suicidal ideation in the past six months will complete laboratory and home-based assessments under varying levels of sleep pressure. Participants will be evaluated during late-night wakefulness and under conditions of both higher and lower sleep pressure. The goal of the study is to better understand the biological and behavioral mechanisms that may contribute to elevated suicide risk during nocturnal wakefulness.
CONDITIONS
Official Title
Mind After Midnight
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18-55 years
- History of suicidal ideation within the past 6 months
- Habitual bedtime between 9:00 PM and 1:00 AM
- Habitual wake time between 6:00 AM and 9:00 AM
- Ability to provide informed consent
You will not qualify if you...
- Current suicidal intent requiring immediate clinical intervention
- Diagnosis of a primary sleep disorder (e.g., untreated obstructive sleep apnea, narcolepsy)
- Bipolar disorder or psychotic disorder
- Substance use disorder within the past 3 months
- Use of medications that significantly affect sleep or circadian rhythms
- Night shift work or transmeridian travel within the past month
- Medical or neurological condition that would interfere with participation
- Pregnancy
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
University of Arizona - Center for Sleep, Circadian, and Neuroscience Research
Tucson, Arizona, United States, 85724
Actively Recruiting
Research Team
D
Denisse Armenta
CONTACT
D
Darilyn Rivera-Collazo, MS
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
CROSSOVER
Primary Purpose
BASIC_SCIENCE
Number of Arms
2
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here