Actively Recruiting

Phase Not Applicable
Age: 18Years - 25Years
All Genders
ID05965622

Targeting Suicidality in Young Adults: a Randomized, Controlled Pragmatic, Multicentre Trial Evaluating the (Cost)-Effectiveness of Attachment Based Family Therapy Compared to Treatment as Usual

Led by Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) · Updated on 2024-08-22

138

Participants Needed

13

Research Sites

52 weeks

Total Duration

On this page

Sponsors

A

Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)

Lead Sponsor

K

KU Leuven

Collaborating Sponsor

AI-Summary

What this Trial Is About

Young adults aged 18 to 25 who experience frequent thoughts about killing themselves are the focus of this study, which evaluates the (cost-)effectiveness of Attachment Based Family Therapy (ABFT) compared to Treatment As Usual (TAU). Suicide is a leading cause of death among young adults, and current treatments have limited success. This trial aims to determine if involving family through ABFT can better reduce suicidality and improve outcomes, informing clinical guidelines and care practices in Belgium and the Netherlands. Participants are randomly assigned to one of two groups: the experimental group receives ABFT as an add-on to TAU, which includes treatments like antidepressants, CBT, or DBT, with weekly ABFT sessions lasting about 16 weeks. The control group receives TAU alone, allowing up to four sessions of systemic family therapy. ABFT focuses on strengthening parent-child attachment bonds to provide a supportive base for young adults, involving parents or caregivers actively in therapy. Throughout the study, suicidality is measured at baseline, immediately after intervention, and at follow-ups 3, 6, and 12 months post-intervention using tools like the Suicidal Ideation Questionnaire Junior. Researchers also assess depressive symptoms, family functioning, attachment, quality of life, and healthcare costs. The trial includes 138 participants across multiple sites, with double-blind randomized allocation. Safety, adherence, and cost-effectiveness are closely monitored during and after the treatment period.

CONDITIONS

Brief Title

(Cost)-Effectiveness of ABFT for Suicidal Youth.

Who Can Participate

Age: 18Years - 25Years
All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • Aged between 18 and 25.
  • Score above 31 on the Suicidal Ideation Questionnaire Junior.
  • Have at least one primary parent or caregiver who participates in assessment and treatment (biological parent, stepparent, grandparent, other relative, or foster parent).
Not Eligible

You will not qualify if you...

  • Severe alcohol or cannabis use disorder, or modest/severe substance use disorder for other substances.
  • Severe conduct disorder.
  • Evidence of psychotic features or prior psychosis.
  • Severe cognitive impairment such as mental retardation or severe developmental disorders.
  • Other circumstances affecting participation, such as severe medical disorders or relocation.

AI-Screening

AI-Powered Screening

Complete this quick 3-step screening to check your eligibility

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Your Study Journey

Screening

Duration - 2 to 4 weeks

Participants are screened for eligibility to participate in the trial.

1 visit (in-person)

Outpatient Treatment

Duration - Approximately 16 weeks

Participants receive weekly sessions of Attachment Based Family Therapy (ABFT) as an add-on to their usual care, or continue with Treatment As Usual (TAU) alone to address suicidality. The therapy focuses on strengthening family relationships and attachment bonds.

Weekly visits for up to 16 weeks

Follow-up

Duration - Up to 12 months after treatment

Participants are monitored after treatment ends to assess the longer-term effects on suicidality, depressive symptoms, family functioning, and other outcomes.

Visits at 3, 6, and 12 months post-treatment

Trial Site Locations

Total: 13 locations

1

Prakijkt ConnectUs

Tongeren, Limburg, Belgium, 3700

Actively Recruiting

2

UGent Centrum Kind en Adolescent

Ghent, Oost-Vlaanderen, Belgium, 9000

Not Yet Recruiting

3

UPC KU Leuven, campus Kortenberg

Kortenberg, Vlaams-Brabant, Belgium, 3070

Actively Recruiting

4

PraxisP

Leuven, Vlaams-Brabant, Belgium, 3000

Not Yet Recruiting

5

STUVO Psychologen en Psychiaters

Leuven, Vlaams-Brabant, Belgium, 3000

Actively Recruiting

6

Praktijk Annemie Uyttersprot

Merchtem, Vlaams-Brabant, Belgium, 1785

Actively Recruiting

7

GGzE

Eindhoven, North Brabant, Netherlands

Actively Recruiting

8

GGZ Oost Brabant

Oss, North Brabant, Netherlands

Actively Recruiting

9

Academisch Medisch Centrum

Amsterdam, North Holland, Netherlands

Not Yet Recruiting

10

Arkin

Amsterdam, North Holland, Netherlands

Actively Recruiting

11

Levvel

Amsterdam, North Holland, Netherlands

Not Yet Recruiting

12

Kenter Jeugdhulp

Santpoort-Noord, North Holland, Netherlands

Actively Recruiting

13

GGz Centraal

Amersfoort, Utrecht, Netherlands

Actively Recruiting

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Research Team

C

Claudi LH Bockting, Professor

N

Nadia Van Der Spek, PhD

How is the study designed?

Study Type

INTERVENTIONAL

Masking

DOUBLE

Allocation

RANDOMIZED

Model

PARALLEL

Primary Purpose

TREATMENT

Number of Arms

2

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Published Research Related To This Trial

The effectiveness and cost-effectiveness of attachment-based family therapy for young adults with high suicidal ideation: protocol of a randomized controlled trial.

Claudi Bockting, Guy Bosmans, Nele Bergers...

https://pubmed.ncbi.nlm.nih.gov/39415182