Exploring How DNF-10 Affects Appetite Through Hormone Regulation in Healthy Adults Aged 20 to 50

What this Trial Is About

Researchers are evaluating the effects of DNF-10, a dietary supplement, on appetite regulation and enteroendocrine hormone activity in healthy adults aged 20 to 50 years with a body mass index between 18.5 and 29.9 kgm. This pilot, proof-of-concept, randomized, double-blind, placebo-controlled crossover study aims to explore DNF-10s potential to influence eating behavior and its physiological relevance. Participants will receive either 250 mgday of DNF-10 or a placebo containing 250 mg maltodextrin per day. The study follows a crossover design where each participant experiences both treatments in separate periods. The trial includes a one-month treatment duration for each period, allowing comparison of DNF-10 and placebo effects on appetite and hormone levels. During the study, participants will be monitored for changes in dysfunctional eating behavior, food intake in response to emotions, entero-hormone biomarker levels, body weight, and waist circumference at baseline and after each treatment period. The study includes careful evaluation of safety and adherence, with data collected over the course of the treatment phases. Total participation time spans multiple months, encompassing both treatment sequences and assessments.

Modulation of Appetite Signaling Through Enterohormone Stimulation by DNF-10