Actively Recruiting
Modulating Explore-Exploit Biases by Improving Mood in Adults With Methamphetamine Use Disorder
Led by Laureate Institute for Brain Research, Inc. · Updated on 2025-09-03
80
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
Sponsors
L
Laureate Institute for Brain Research, Inc.
Lead Sponsor
N
National Institute of General Medical Sciences (NIGMS)
Collaborating Sponsor
AI-Summary
What this Trial Is About
Researchers are studying adults with methamphetamine use disorder (MUD) to understand how mood affects decision-making during tasks that require balancing exploring new options and exploiting known rewards. The study investigates whether recalling positive personal memories can improve mood, reduce negative feelings, and normalize brain activity related to these decision-making behaviors. This is a randomized, double-blind, sham-controlled trial involving 80 adults currently in abstinence-only treatment for MUD. Participants are randomly assigned to one of two groups: one group recalls happy, positive autobiographical memories that are emotionally pleasurable and not related to drugs, while the other group recalls neutral, emotionally neutral autobiographical memories. The mood modulation is assessed through behavioral tasks and brain imaging using functional magnetic resonance imaging (fMRI) during decision-making exercises before and after the mood recall intervention. During the study, participants undergo assessments of their affective state, learning rates, brain responses to rewards and punishments in specific brain regions, and decision-making performance. These measurements are taken at multiple time points on the same day, including before the intervention and up to 90 minutes afterward. The study aims to track changes in mood, brain activity, and decision-making behaviors to better understand how mood improvements might influence cognitive function in people with MUD.
CONDITIONS
Brief Title
Mood and Decision-making in Methamphetamine Use Disorder
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adults 18-65 years old
- Able to speak and understand English
- Diagnosed with methamphetamine use disorder in the past year
- Currently enrolled in treatment for substance use disorder
You will not qualify if you...
- Severe traumatic brain injury as indicated by a specific screening score
- Medical conditions that interfere with study participation
- Diagnosis of psychotic disorders, bipolar I disorder, or major depressive disorder with psychosis
- Contraindications for MRI scanning
- Positive tests for alcohol or drugs (except cannabis or prescribed benzodiazepines)
- Inability to comply with study procedures as judged by the researchers
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - 1 day
Participants undergo mood modulation using autobiographical memory recall to improve mood and affective state, followed by behavioral and brain response assessments.
1 baseline visit and 1 follow-up visit on the same day
Trial Site Locations
Total: 1 location
1
Laureate Institute for Brain Research
Tulsa, Oklahoma, United States, 74136
Actively Recruiting
Research Team
M
Maëlle CM Gueguen, PhD
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
BASIC_SCIENCE
Number of Arms
2
Similar Trials
Frequently Asked Questions
Have more questions? Get in touch with our team for quick support
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here