Actively Recruiting
Mood and Decision-making in Methamphetamine Use Disorder
Led by Laureate Institute for Brain Research, Inc. · Updated on 2025-09-03
80
Participants Needed
1
Research Sites
152 weeks
Total Duration
On this page
Sponsors
L
Laureate Institute for Brain Research, Inc.
Lead Sponsor
N
National Institute of General Medical Sciences (NIGMS)
Collaborating Sponsor
AI-Summary
What this Trial Is About
In this project, the investigators examine behavior and associated brain activity during explore-exploit decision-making tasks performed pre- and post-modulation of affective state using autobiographical memory recall. The investigators hypothesize that a positive memory recall will reduce negative affective state, reduce explore-exploit biases and normalize the associated brain activity. The investigators propose a randomized double-blind, sham-controlled trial of positive autobiographical memory recall with 80 adults (n=40 per arm) with methamphetamine use disorder (MUD) currently involved in abstinence only treatment centers.
CONDITIONS
Official Title
Mood and Decision-making in Methamphetamine Use Disorder
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adults 18-65 years old
- Proficient in English as evaluated during screening
- Diagnosis of DSM-5 methamphetamine use disorder in the past year confirmed by MINI
- Currently enrolled in treatment for substance use disorder
You will not qualify if you...
- Severe traumatic brain injury indicated by a score 653 on the Tulsa Head Injury Screen
- Medical conditions interfering with study participation per medical screening
- Diagnosed with psychotic disorders, bipolar I disorder, or major depressive disorder with psychosis
- Contraindications for fMRI as listed on MR screening form
- Positive breathalyzer test for alcohol
- Positive urine drug screen except for cannabis or prescribed benzodiazepines
- Inability to comply with study procedures based on experimenter judgment
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Laureate Institute for Brain Research
Tulsa, Oklahoma, United States, 74136
Actively Recruiting
Research Team
M
Maëlle CM Gueguen, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
BASIC_SCIENCE
Number of Arms
2
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