Actively Recruiting

Phase Not Applicable
Age: 6Months - 54Months
All Genders
Healthy Volunteers
ID06599580

Mother Screening for Relapse Using Mid-upper Arm Circumference Among Children Recovered From Severe Acute Malnutrition

Led by University of California, San Francisco · Updated on 2025-11-20

2400

Participants Needed

1

Research Sites

N/A

Total Duration

On this page

Sponsors

U

University of California, San Francisco

Lead Sponsor

C

Centre de Recherche en Sante de Nouna, Burkina Faso

Collaborating Sponsor

AI-Summary

What this Trial Is About

This research investigates training caregivers to screen children who have recovered from severe acute malnutrition (SAM) using mid-upper arm circumference (MUAC) tapes. The study aims to find out if this training can reduce relapse risk to moderate or severe acute malnutrition and improve early detection times. It also evaluates how acceptable this screening method is to both caregivers and clinics. The trial involves children aged 6 to 54 months who recently recovered from uncomplicated SAM treated in outpatient programs. Participants are randomized into three groups: one receives usual care with no caregiver MUAC training and monthly clinic visits for 3 months plus a follow-up at 6 months; the second group receives caregiver MUAC screening training with weekly home screening plus the usual monthly clinic visits and a 6-month follow-up; the third group also receives caregiver MUAC screening training but with a reduced clinic visit schedule, attending only at 3 and 6 months post enrollment. Caregivers are counseled to bring their child to the clinic if their child's MUAC falls below 11.5 cm, indicating relapse. During the 6 months following enrollment, caregivers will screen their children weekly at home if trained, and all children will be assessed clinically at 3 and 6 months for outcomes. Researchers will measure relapse incidence, time to relapse detection, and anthropometric outcomes. Surveys will assess caregiver acceptance of MUAC training. The study plans to enroll 1200 caregiver-child pairs to better understand if caregiver screening improves relapse detection and child health after SAM recovery.

CONDITIONS

Brief Title

Mother Screening for Relapse Using Mid-upper Arm Circumference Among Children Recovered From Severe Acute Malnutrition (Full Scale Trial)

Who Can Participate

Age: 6Months - 54Months
All Genders
Healthy Volunteers

Eligibility Criteria

Eligible

You may qualify if you...

  • Caregivers aged 18 years or older or a legal guardian or relative aged 18 or older
  • Child aged between 6 and 54 months
  • Child has recovered from severe acute malnutrition according to national guidelines (weight-for-height ≥ -2 and/or mid-upper arm circumference ≥ 12.5 cm in the past month)
  • Family plans to remain in the study area for 6 months
  • Appropriate consent is provided by caregiver or guardian
Not Eligible

You will not qualify if you...

  • Caregiver or legal guardian or relative younger than 18 years old
  • Child younger than 6 months or older than 54 months
  • Twins or multiple births
  • Children with feeding issues
  • Child did not recover from severe acute malnutrition in the past month
  • Family plans to move out of the study area within 6 months
  • Caregiver or guardian refuses to provide consent

AI-Screening

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Your Study Journey

Screening

Duration - 2 to 4 weeks

Participants are screened for eligibility to participate in the trial.

1 visit (in-person)

Caregiver Training and Screening

Duration - 6 months

Caregivers are trained to screen their children for malnutrition relapse using mid-upper arm circumference tapes and asked to perform weekly screenings at home.

Weekly home screenings by caregivers

Follow-up

Duration - 6 months

Participants attend clinic visits to monitor child health with varying schedules depending on the assigned study arm.

Monthly clinic visits for 3 months and 1 visit at 6 months (standard schedule) or 1 visit at 3 months and 1 visit at 6 months (reduced schedule)

Trial Site Locations

Total: 1 location

1

Centre de recherche en sante de nouna

Nouna, Burkina Faso

Actively Recruiting

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Research Team

C

Catherine Oldenburg, ScD

H

Hadley Burroughs

How is the study designed?

Study Type

INTERVENTIONAL

Masking

SINGLE

Allocation

RANDOMIZED

Model

PARALLEL

Primary Purpose

OTHER

Number of Arms

3

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