Hydroxyurea: effects on hemoglobin F production in patients with sickle cell anemia.
S Charache, G J Dover, R D Moore...
https://pubmed.ncbi.nlm.nih.gov/1375104Completed
Phase 3
Age: 18Years - 50Years
All Genders
ID00000586
Multicenter Study of Hydroxyurea in Patients With Sickle Cell Anemia (MSH)
Led by National Heart, Lung, and Blood Institute (NHLBI) · Updated on 2016-04-14
N/A
Participants Needed
N/A
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
To assess the efficacy and safety of orally administered hydroxyurea in the treatment of painful crises in patients with sickle cell anemia.
CONDITIONS
Official Title
Multicenter Study of Hydroxyurea in Patients With Sickle Cell Anemia (MSH)
Who Can Participate
Age: 18Years - 50Years
All Genders
Eligibility Criteria
You may qualify if you...
Men and women, ages 18 to 50, who had at least three emergency room visits or hospitalizations for sickle cell anemia during the year prior to recruitment. Patients with greater than 20 crises per year were included. A total of 295 patients had Hb ss and four had Hb SB thalassemia.
You will not qualify if you...
History of severe allergic reactions to study medication Currently pregnant or breastfeeding Recent participation in another clinical trial within the last 30 days Presence of uncontrolled medical conditions that could affect safety
Trial Site Locations
Site Locations not provided
Location information for this trial is currently unavailable.
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
N/A
Primary Purpose
TREATMENT
Number of Arms
0
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Published Research Related To This Trial
Fetal hemoglobin in sickle cell anemia: relation to regulatory sequences cis to the beta-globin gene. Multicenter Study of Hydroxyurea.
Z H Lu, M H Steinberg
https://pubmed.ncbi.nlm.nih.gov/8608254Effect of hydroxyurea on the frequency of painful crises in sickle cell anemia. Investigators of the Multicenter Study of Hydroxyurea in Sickle Cell Anemia.
S Charache, M L Terrin, R D Moore...
https://pubmed.ncbi.nlm.nih.gov/7715639Design of the multicenter study of hydroxyurea in sickle cell anemia. Investigators of the Multicenter Study of Hydroxyurea.
S Charache, M L Terrin, R D Moore...
https://pubmed.ncbi.nlm.nih.gov/8925656Effects of hydroxyurea administration on the body weight, body composition and exercise performance of patients with sickle-cell anaemia.
A C Hackney, W Hezier, T P Gulledge...
https://pubmed.ncbi.nlm.nih.gov/9176021Fetal hemoglobin in sickle cell anemia: determinants of response to hydroxyurea. Multicenter Study of Hydroxyurea.
M H Steinberg, Z H Lu, F B Barton...
https://pubmed.ncbi.nlm.nih.gov/9028341Mechanism of action of hydroxyurea in the management of sickle cell anemia in adults.
S Charache
https://pubmed.ncbi.nlm.nih.gov/9317197An extension of stochastic curtailment for incompletely reported and classified recurrent events: the Multicenter Study of Hydroxyurea in Sickle Cell Anemia (MSH).
R P McMahon, M A Waclawiw, N L Geller...
https://pubmed.ncbi.nlm.nih.gov/9315425Cost-effectiveness of hydroxyurea in sickle cell anemia. Investigators of the Multicenter Study of Hydroxyurea in Sickle Cell Anemia.
R D Moore, S Charache, M L Terrin...
https://pubmed.ncbi.nlm.nih.gov/10815784Effect of hydroxyurea on mortality and morbidity in adult sickle cell anemia: risks and benefits up to 9 years of treatment.
Martin H Steinberg, Franca Barton, Oswaldo Castro...
https://pubmed.ncbi.nlm.nih.gov/12672732