Study of Molecular and Immune Profiles in Heart Muscle Diseases Using Endomyocardial Biopsies

What this Trial Is About

Researchers are investigating molecular markers and immune signaling molecules in various heart muscle diseases including cardiomyopathies, myocarditis, cardiac amyloidosis, and the post-heart transplantation course. This observational study aims to improve diagnosis and therapy by identifying specific molecular profiles such as proteome, lipidome, and metabolome changes associated with these conditions. Participants who are already scheduled to receive an endomyocardial biopsy as part of their regular medical care will be included. An additional biopsy sample will be collected for research purposes, which will be analyzed using multi-omics methods, immune signaling analysis, and nuclear cardiology techniques. These analyses seek to detect genetic mutations, inflammatory gene patterns, and protein alterations, and results will be compared to clinical parameters and biomarkers. During the study, participants will undergo the biopsy procedure along with their routine clinical care. Researchers will measure spatial molecular profiles and immune signaling at the start and follow participants for up to one year. Secondary outcomes include tracer uptake analysis in cardiac amyloidosis. The study is observational and involves no experimental treatments, focusing instead on collecting and analyzing biopsy samples to better understand myocardial diseases.

Multimodal Analysis of Endomyocardial Biopsies