Actively Recruiting
Multispectral Optoacoustic Tomography for Advanced Imaging of Centronuclear Myopathy
Led by University of Erlangen-Nürnberg Medical School · Updated on 2025-06-15
40
Participants Needed
1
Research Sites
60 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Centronuclear myopathy (CNM) is a rare congenital muscle disorder characterized by muscle weakness and abnormal placement of nuclei in muscle cells. This research aims to gather detailed molecular information about muscle degeneration in CNM patients using a new imaging method called multispectral optoacoustic tomography (MSOT). The study includes 20 CNM patients and 20 healthy individuals matched by age and sex to compare muscle characteristics. Participants will undergo physical exams, clinical and functional tests, and MSOT imaging at various muscle sites including paraspinal, trapezius, deltoid, forearm flexors, quadriceps, adductor, hamstrings, triceps surae, and tibialis anterior muscles. MSOT is a non-invasive technique using near-infrared light pulses to produce ultrasound waves, enabling detailed visualization of muscle components like collagen, myoglobin, and hemoglobin. The study will collect data during a single visit on day 1. During the visit, researchers will measure muscle strength, perform timed functional tests, and conduct MSOT scans at predefined muscle locations. They will analyze optoacoustic spectra and compare signals from hemoglobin, myoglobin, lipids, and collagen. Correlations with disease duration, age, and muscle strength will also be assessed. Participation involves one study day with examinations and imaging, with no invasive procedures or anesthesia required.
CONDITIONS
Brief Title
Multispectral Optoacoustic Tomography for Advanced Imaging of Centronuclear Myopathy
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Diagnosed with centronuclear myopathy (CNM)
- At least 2 years of age
- For healthy volunteers: at least 2 years of age
You will not qualify if you...
- Pregnancy
- Nursing mothers
- Tattoo in the area of the examination field
- Subcutaneous fatty tissue thicker than 3 cm
- For healthy volunteers: any signs or history of muscle diseases
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - 1 day
Participants undergo non-invasive multispectral optoacoustic tomography (MSOT) imaging and clinical-functional tests including muscle strength testing and the timed "get up and go" test to assess muscle structure and disease extent.
1 visit (in-person)
Duration - Up to 6 months
Participants may be followed over time to gain molecular insights into muscle degeneration in centronuclear myopathy.
Additional visits depending on study protocol
Trial Site Locations
Total: 1 location
1
Uniklinikum Erlangen
Erlangen, Bavaria, Germany, 91054
Actively Recruiting
Research Team
L
Lina Tan
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
Similar Trials
Frequently Asked Questions
Have more questions? Get in touch with our team for quick support
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here