Actively Recruiting
Muscle Recovery After Critical Illness
Led by Kirby Mayer · Updated on 2025-11-24
209
Participants Needed
3
Research Sites
249 weeks
Total Duration
On this page
Sponsors
K
Kirby Mayer
Lead Sponsor
N
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Collaborating Sponsor
AI-Summary
What this Trial Is About
The overarching goal of the proposed study is to determine the trajectories of physical recovery and cellular markers involved with the underlying failure to recover muscle after critical illness, while exploring which characteristics are associated with sustained physical disability. This proposal will examine muscle pathophysiology carefully aligned with physical function outcomes in order to longitudinally assess the recovery, or failed recovery, of muscle function in participants after critical illness: 1. to examine the recovery of muscle and physical function in ICU survivors through longitudinal assessments 2. to investigate the underlying cellular markers and mechanisms of muscle recovery in ICU survivors 3. to determine which cellular markers contribute to physical disability in ICU survivors up to 1 year after hospital admission
CONDITIONS
Official Title
Muscle Recovery After Critical Illness
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adults older than 18 years
- Admission to ICU for sepsis or acute respiratory failure
- ICU stay lasting at least 72 hours
You will not qualify if you...
- Acute or chronic neurological conditions
- Acute or chronic orthopedic conditions preventing strength or functional testing
- Patients who were not ambulatory before ICU admission
- Patients not expected to survive about 6 months after admission
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 3 locations
1
University of Alabama at Birmingham
Birmingham, Alabama, United States, 35005
Active, Not Recruiting
2
University of Kentucky
Lexington, Kentucky, United States, 40536
Actively Recruiting
3
Oklahoma Medical Research Foundation
Oklahoma City, Oklahoma, United States, 73113
Active, Not Recruiting
Research Team
K
Kirby P Mayer, PhD
CONTACT
D
Doug Long, MS
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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