Study of Clinical Profiles and Natural History in Patients with Chronic Hypereosinophilia and Hypereosinophilic Syndrome A National Cohort Observational Study

What this Trial Is About

Researchers are studying the natural history and clinical profiles of patients with unexplained chronic hypereosinophilia HE and hypereosinophilic syndromes HES, which can affect organs like the heart, lungs, and skin or sometimes show no organ involvement. These conditions vary widely in their progression and response to treatment, and the study aims to better understand the genetic and environmental factors involved, especially those supporting temporary or persistent HEHES without identifiable external triggers. This observational study involves patients diagnosed with HE or HES, including those with specific organ eosinophilic diseases, followed over a long period to monitor their clinical manifestations and disease evolution. Participants provide additional blood samples for biobanking to support research on genetic variants, serum biomarkers, and gene expression profiles. The study collects comprehensive data to describe frequency patterns of clinical symptoms, complications, and organ damage across different age groups. Participants will be followed for up to 10 years, with ongoing monitoring of their clinical symptoms and organ involvement. Researchers will assess various outcomes including the frequency of different clinical manifestations at diagnosis and during follow-up, evolutionary profiles of the disease, and genetic markers related to HEHES. The study includes regular evaluations, biological sample collection, and analysis of membrane activation markers and gene expression differences between symptomatic and asymptomatic patients to gain insights into disease mechanisms.

Natural History of Hypereosinophilia and Hypereosinophilic Syndromes