Study to Understand the Natural History and Progression of Synucleinopathies Including Parkinson Disease, Dementia with Lewy Bodies, and Multiple System Atrophy

What this Trial Is About

Synucleinopathies are rare neurodegenerative diseases characterized by worsening neurological problems and abnormal buildup of the protein alpha-synuclein in the nervous system. They usually begin after age 50 and often cause slow movement, coordination issues, or mild cognitive decline. Conditions such as Parkinson disease, dementia with Lewy bodies, and multiple system atrophy fall under synucleinopathies. In some cases, symptoms start with autonomic nerve problems like unexplained constipation or low blood pressure upon standing before affecting the brain. This observational study follows people diagnosed with synucleinopathies or those in an early pre-motor phase showing only autonomic symptoms or REM sleep behavior disorder. Participants will have regular visits at specialized centers to document their clinical features and collect biological markers. The goal is to understand how these diseases progress, identify markers that predict brain involvement, and define the natural history of multiple system atrophy. Participants will undergo thorough evaluations including clinical assessments and biological testing over time. Researchers will monitor symptoms, neurological function, and autonomic signs to track disease progression. The study aims to create a detailed database of patients with autonomic disorders and identify biomarkers that may predict disease spread. Follow-up will help clarify which patients develop motor or cognitive problems and which remain stable, aiding future clinical trials and treatments.

Natural History Study of Synucleinopathies