Actively Recruiting
Neural Mechanisms of Interpersonal Expectations on Negative Affect
Led by Trustees of Dartmouth College · Updated on 2026-04-24
190
Participants Needed
1
Research Sites
130 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The goal of this clinical trial is to learn whether non-invasive brain stimulation, called transcranial temporal interference stimulation (tTIS), can reduce negative affect, and how expectations shaped by care providers influence these effects. The main questions this study aims to answer are: (1)Does active tTIS reduce negative affect more effectively than sham (inactive) tTIS? (2)Do positive treatment expectations enhance the effects compared to negative expectations? Participants will: (1) Receive either active or sham tTIS. (2) Be provided with positive or negative messaging regarding treatment effectiveness. (3) Interact with care providers and complete assessments measuring negative affect and physiological responses.
CONDITIONS
Official Title
Neural Mechanisms of Interpersonal Expectations on Negative Affect
Who Can Participate
Eligibility Criteria
You may qualify if you...
- 'Doctors' must be medical students at Geisel School of Medicine or resident physicians at Dartmouth Hitchcock Medical Center
- Participants must be able to perform study tasks and be fluent or native English speakers
- Participants must tolerate the maximum level of thermal pain stimuli used in the study
- Participants aged between 18 and 55 years
You will not qualify if you...
- Current or past diagnosis of depression, bipolar disorder, or other psychiatric conditions
- Current seizure disorder or history of stroke or other major neurological diseases causing cognitive impairment
- Current chronic pain, acute pain within three months, or migraine disorder (15 or more headache days per month)
- Use of medications affecting the central nervous system or for neurological/psychiatric treatment
- Substance abuse within the last six months
- Contraindications to MRI or tTIS such as pregnancy, claustrophobia, pacemakers, implants, metal injuries, brain abnormalities, or scalp skin lesions
- Contraindications for induced pain including heart disease, high blood pressure, heart surgery, respiratory problems, fibromyalgia, Raynaud's Syndrome, diabetes
AI-Screening
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Trial Site Locations
Total: 1 location
1
Dartmouth College, Department of Psychological and Brain Sciences
Hanover, New Hampshire, United States, 03755
Actively Recruiting
Research Team
Z
Zhaoxing Wei, Ph.D.
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
TRIPLE
Allocation
RANDOMIZED
Model
CROSSOVER
Primary Purpose
BASIC_SCIENCE
Number of Arms
6
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