Actively Recruiting
Neurocognitive Outcomes After Whole Brain Radiation Therapy for Hematologic Malignancies
Led by M.D. Anderson Cancer Center · Updated on 2026-05-20
100
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
This research aims to understand how whole brain radiation therapy (WBRT) affects memory and thinking skills in patients with blood cancers such as leukemia, lymphoma, and myeloma. The study focuses on patients treated for hematologic malignancies affecting the brain and seeks to track cognitive changes over time. It also explores quality of life, brain imaging changes, and the impact of medications like Memantine on cognitive function. Participants will undergo neurocognitive testing and complete questionnaires lasting 8 to 10 minutes at several time points: before starting WBRT, then at 2, 6, and 12 months after treatment, followed by annual check-ins for up to 5 years. Standard brain MRIs are also performed at these intervals to observe any changes. The study uses standard-of-care assessments and imaging without additional experimental treatments. During the study, participants will complete cognitive tests, quality-of-life questionnaires, and have brain MRIs to monitor effects over time. Researchers will assess memory and thinking abilities, quality of life, MRI changes, and the role of medications used for cognitive support. The total follow-up period can last up to 5 years, allowing detailed long-term monitoring after WBRT for blood cancers.
CONDITIONS
Brief Title
Neurocognitive Outcomes After Whole Brain Radiation Therapy for Hematologic Malignancies
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18 years or older
- Treatment with radiation therapy to the brain for a hematologic malignancy (e.g., primary or secondary central nervous system lymphoma, leukemia, myeloma)
- Able and proficient in English to complete tests
- Claustrophobia managed with medication is allowed
- Cognitive impairments managed with medication are allowed
- Pregnant patients are eligible
You will not qualify if you...
History of severe allergic reactions to study medication Currently pregnant or breastfeeding Recent participation in another clinical trial within the last 30 days Presence of uncontrolled medical conditions that could affect safety
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Up to 5 years
Participants undergo neurocognitive function assessments, complete questionnaires and have MRI scans as part of standard care. These assessments monitor cognitive outcomes, quality of life, and brain changes after whole brain radiation therapy.
Baseline visit within 4 weeks before radiation therapy, then visits at 2, 6, 12 months after radiation therapy completion, and annually for 5 years
Trial Site Locations
Total: 1 location
1
M D Anderson Cancer Center
Houston, Texas, United States, 77030
Actively Recruiting
Research Team
D
Dustin M Silk
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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