Registry for Patients With Antibody-mediated Neuroimmunological Diseases

What this Trial Is About

Researchers are investigating the presence and role of antineuronal antibodies in various neurological diseases that currently lack a clear cause. The study focuses on understanding whether these antibodies are common and disease-specific, their relationship to infections like HSV, their importance in disease development, and how patients with these antibodies respond to treatment. This work aims to improve knowledge about autoimmune encephalitis and related neurological conditions in both adults and children. Participants include patients suspected of having neuroimmunological diseases who require lumbar puncture as part of their routine clinical evaluation. The study collects cerebrospinal fluid (CSF) samples for detailed antibody analysis using several advanced laboratory methods, including immunofluorescence staining, immunoprecipitation, and flow cytometry. Clinical data and follow-up information are also gathered over several years to monitor disease progression and treatment outcomes. During the study, researchers assess antibody presence and characteristics in CSF samples at recruitment. They also collect clinical information and evaluate neurological symptoms such as ataxia, psychiatric and motor symptoms at multiple time points up to five years. The study records details about immunotherapy treatments and monitors disease course using laboratory tests, imaging, and patient evaluations, all contributing to a comprehensive understanding of these neurological disorders.

Neuroimmunology Registry and Biobank