Actively Recruiting
Neuroimmunology Registry and Biobank
Led by Charite University, Berlin, Germany · Updated on 2025-05-06
300
Participants Needed
2
Research Sites
543 weeks
Total Duration
On this page
Sponsors
C
Charite University, Berlin, Germany
Lead Sponsor
U
University of Ulm
Collaborating Sponsor
AI-Summary
What this Trial Is About
A variety of antineuronal antibodies have been detected in the cerebrospinal fluid (CSF) of patients with neurological diseases. This raises the question of whether these antibodies are disease-specific or merely an epiphenomenon of inflammatory processes in the brain. The registry was established with the following objectives: \[1\] Are antineuronal antibodies much more common than previously thought in various neurological disorders for which the etiology has not yet been elucidated? \[2\] Can further correlations, such as those between HSV infection and NMDA receptor autoimmunity, be identified? \[3\] Are these antibodies mainly non-specific epiphenomena or are they crucial for the pathogenesis? \[4\] What is the clinical course of patients with antineuronal antibodies and their response to therapy? These questions will be addressed in a broad immunohistological screening of a large number of CSF samples and a clinical database of patients with neurological disorders.
CONDITIONS
Official Title
Neuroimmunology Registry and Biobank
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Suspected neuroimmunological disease requiring lumbar puncture for diagnosis and treatment decision
- Unclear clinical diagnosis needing additional cerebrospinal fluid collection for B cell isolation and monoclonal antibody production
- All age groups are eligible
- Both male and female patients are eligible
You will not qualify if you...
- Withdrawal of consent
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 2 locations
1
Charité - Universitätsmedizin Berlin
Berlin, State of Berlin, Germany, 13353
Actively Recruiting
2
Universität Ulm
Ulm, Germany, 89081
Actively Recruiting
Research Team
M
Markus Schuelke, MD
CONTACT
M
Marc Nikolaus, MD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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