Studying Nitric Oxide Levels to Predict Brain Vessel Narrowing After Aneurysmal Subarachnoid Hemorrhage

What this Trial Is About

This research aims to understand whether levels of nitric oxide consumption can predict cerebral vasospasm in patients who have suffered an aneurysmal subarachnoid hemorrhage SAH. The study compares nitric oxide consumption between patients with SAH and those without, using cerebral spinal fluid samples to analyze these levels. This observational study is conducted to explore the potential relationship between nitric oxide use and the occurrence of vasospasm, an important complication of SAH. Participants with SAH will have daily samples of their cerebral spinal fluid collected through an external ventricular drainage system for 15 days following their hemorrhage. These samples will be stored and analyzed to measure nitric oxide consumption. Daily Transcranial Doppler monitoring will check for cerebral vasospasm, and CT angiography will be used when vasospasm is suspected or in comatose patients after four days. A control group of patients undergoing spinal anesthesia without neurological issues will also provide a single cerebral spinal fluid sample during their procedure. Throughout the study, researchers will collect demographic and clinical data from all participants. They will monitor nitric oxide consumption daily for SAH patients and once for controls, alongside assessments for cerebral vasospasm. Secondary measures include nitric oxide metabolite levels and free hemoglobin. Participants are observed for 15 days, with safety and technical monitoring in place. The study aims to classify participants into groups based on the presence or absence of vasospasm and SAH, providing insights into the predictive value of nitric oxide consumption.

Nitric Oxide Consumption as a Predictor of Vasospasm in Subarachnoid Hemorrhage