Actively Recruiting

Phase Not Applicable
Age: 65Years +
All Genders
ID05993754

Impact of Non-pharmacological Nursing Measures to Reduce Postoperative Delirium in Frail Elderly Undergoing Elective Non-cardiac Surgery

Led by Pontificia Universidad Catolica de Chile · Updated on 2025-06-10

400

Participants Needed

1

Research Sites

N/A

Total Duration

On this page

AI-Summary

What this Trial Is About

This research aims to evaluate the effect of non-drug measures applied by nursing teams to reduce the risk of postoperative delirium (POD) in frail and pre-frail elderly people over 65 years old who undergo elective non-cardiac surgery. Frailty increases the risk of postoperative complications, including delirium, which can worsen recovery and increase mortality. The study addresses a gap in routine frailty assessment and seeks to improve outcomes by applying targeted nursing interventions during the post-surgical period. Participants will be randomly assigned to one of two groups: one group will receive a set of non-pharmacological interventions delivered by the nursing team, including sensory correction (use of glasses, hearing aids, dental prostheses), reorientation, early mobilization, environmental management, sleep promotion, and reduction of anticholinergic drugs. The other group will receive traditional postoperative care. Both groups will be monitored during surgery with electroencephalographic tools to guide anesthesia and maintain stable blood pressure and temperature. During the postoperative period, participants will undergo cognitive and delirium assessments at multiple time points up to 24 hours after anesthesia. The nursing team will apply cognitive stimulation and mobilization activities, coordinate visits, and monitor sleep. Delirium evaluations will be performed independently by staff not involved in the interventions. If delirium is detected, further geriatric consultation and care adjustments will be made. The study measures postoperative delirium incidence as the primary outcome, with additional cognitive and frailty assessments before surgery and monitoring of anesthesia and pain levels after surgery.

CONDITIONS

Brief Title

Non-pharmacological Prevention of POD in Frailty Elderly Undergoing Elective Surgery Applied by Nursing Teams

Who Can Participate

Age: 65Years +
All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • Patients older than 65 years
  • Scheduled for elective non-cardiac surgery
  • Receiving general anesthesia with Bilateral BIS or SedLine EEG monitoring
  • Classified as ASA I, II, or III
Not Eligible

You will not qualify if you...

  • Neurosurgical patients
  • History of alcohol and/or drug abuse
  • History of recreational psychoactive drug use
  • Allergy to anesthetic drugs

AI-Screening

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Your Study Journey

Screening

Duration - 2 to 4 weeks

Participants are screened for eligibility to participate in the trial.

Preoperative Assessment and Frailty Screening

Duration - Same day as surgery

Participants undergo frailty assessments and cognitive screening on the day of surgery before anesthesia.

1 visit (in-person)

Treatment

Duration - Day of surgery and immediate postoperative period

Participants receive either non-pharmacological nursing interventions to prevent postoperative delirium or traditional care during and after elective non-cardiac surgery under general anesthesia.

1 surgical visit and multiple postoperative assessments within 24 hours

Postoperative Follow-up

Duration - Up to 24 hours after surgery

Participants are monitored for postoperative delirium using standardized assessments at multiple time points up to 24 hours after surgery. Non-pharmacological measures may be continued if delirium is detected.

Delirium evaluations at 10, 60, 120 minutes, and at 12 and 24 hours post-anesthesia

Trial Site Locations

Total: 1 location

1

Pontificia Universidad Catolica de Chile

Santiago, Santiago Metropolitan, Chile, 8330024

Actively Recruiting

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Research Team

V

Victor Contreras, MSN

K

Karen Azagra, BcS

How is the study designed?

Study Type

INTERVENTIONAL

Masking

DOUBLE

Allocation

RANDOMIZED

Model

PARALLEL

Primary Purpose

PREVENTION

Number of Arms

2

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