Normal-pressure Hydrocephalus Relationship Between Sleep Apnea and Intracranial and Intraabdominal Pressures Outcome Prognostic Factors in CSF Shunting Features Guiding to Implant a Ventricle-peritoneal Versus a Ventriculo-atrial Shunt

What this Trial Is About

Normal-pressure hydrocephalus is a condition in adults characterized by symptoms like gait problems, urinary incontinence, and dementia. This condition is linked to increased intracranial pressure during sleep, especially in relation to obstructive sleep apnea. Researchers are studying how sleep apnea affects intracranial and intra-abdominal pressures and how these pressures influence cerebrospinal fluid (CSF) shunting treatments. The study aims to determine the best type of shunt and drainage location to improve treatment outcomes and understand the interaction between sleep apnea and hydrocephalus symptoms. The study compares patients with normal-pressure hydrocephalus who have sleep apnea to those who do not. All participants receive a CSF shunt diversion procedure, where fluid is drained from the brain to either the abdominal cavity or the heart. Researchers will analyze pressure changes during sleep and sleep apnea episodes to decide which shunt type and drainage site are most effective. The study will also evaluate whether treating sleep apnea improves hydrocephalus symptoms. Participants will undergo assessments measuring changes in hydrocephalus symptoms using the Mini-Mental State Examination and the NPH scale within 1 to 2 months after CSF shunt insertion. The study monitors intracranial and intra-abdominal pressures during sleep, particularly during apnea episodes. This monitoring helps understand CSF flow dynamics at night and guides decisions on the type of shunt valve and drainage location. The total study duration and follow-up details are based on these evaluations to assess symptom changes and treatment impact.

Normal Pressure Hydrocephalus and Sleep Apnea