Actively Recruiting
Novel Pulmonary Imaging of Lung Structure and Function in E-cigarette Smokers
Led by Western University, Canada · Updated on 2025-08-14
150
Participants Needed
1
Research Sites
254 weeks
Total Duration
On this page
Sponsors
W
Western University, Canada
Lead Sponsor
L
London Health Sciences Centre
Collaborating Sponsor
AI-Summary
What this Trial Is About
This is a longitudinal study of the long-term health impact of e-cigarette smoking on the lungs. Participants will be followed over a period of 5 years, and impacts of e-cigarette smoking on the lungs will be measured with magnetic resonance imaging (MRI) using hyperpolarized xenon-129 gas, pulmonary function tests, exercise capacity, computed tomography images and questionnaires.
CONDITIONS
Official Title
Novel Pulmonary Imaging of Lung Structure and Function in E-cigarette Smokers
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Written informed consent must be obtained before any study assessments.
- Male and female participants aged 16 years or older.
- Participants who have recently started vaping, with weekly use for more than 1 year and less than 5 years.
- 70 participants must be never users of conventional cigarettes.
- 70 participants must be former or current conventional cigarette users.
- 10 healthy asymptomatic controls matched by age and sex who have never used e-cigarettes or conventional cigarettes.
You will not qualify if you...
- Participants with contraindications to MRI, including MRI-sensitive implants, tattoos with MRI-sensitive dye, or severe claustrophobia.
- Participants who are mentally or legally incapacitated, preventing informed consent or comprehension of written materials.
- Participants unable to perform spirometry or plethysmography maneuvers.
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Robarts Research Institute; The University of Western Ontario; London Health Sciences Centre
London, Ontario, Canada, N6A 5B7
Actively Recruiting
Research Team
G
Grace E Parraga, PhD
CONTACT
A
Angela Wilson, RRT
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
3
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