Study of the Eyes Microbiome and Immune System in Adults with and without Dry Eye Disease

What this Trial Is About

Researchers are studying the ocular microbiome and the local immune system in people with and without dry eye disease to better understand their relationship. Dry eye disease is common and difficult to treat, with inflammation playing a key role. The study aims to find links between changes in the eyes microbiome and immune system that may contribute to dry eye disease. Participants include people with dry eye disease and healthy controls without the condition. The study involves characterizing the types and functions of bacteria on the eyes surface and analyzing tear fluid and eye tissue to assess immune system activity. These evaluations occur at the start of the study to compare both groups. During the study, participants will undergo assessments of their eye bacteria and immune system through tear fluid tests, tissue exams, and molecular analyses. Researchers will measure differences and correlations between the ocular microbiome and immune system in both groups. The study is observational and involves no drug treatments, focusing on collecting detailed biological data to improve understanding of dry eye disease.

Ocular Microbiome and Immune System in Dry Eyes