Comparing Oral Misoprostol, Vaginal Estrogen, and No Cervical Preparation Before Office Hysteroscopy in Postmenopausal Women

What this Trial Is About

Researchers are evaluating different cervical preparation methods before office hysteroscopy in postmenopausal women who are being checked for intrauterine conditions. The study aims to find out if cervical preparation improves the success of the hysteroscopy and which method offers better pain tolerance during the procedure. Four preparation strategies are compared, including vaginal estrogen for 7 or 14 days, oral misoprostol, and no preparation. Participants are randomly assigned to one of four groups no cervical preparation, sublingual misoprostol 200 micrograms given 2 hours before the procedure, vaginal estrogen 20 micrograms once daily for 7 days, or vaginal estrogen 20 micrograms once daily for 14 days before the hysteroscopy. The hysteroscopy uses a no touch vaginoscopic approach without anesthesia. During the study, participants will have pain measured using a visual analog scale during and after the procedure. Researchers will record the success of the hysteroscopy, procedure duration, bleeding, and any complications occurring during or within 24 hours after the procedure. Patient satisfaction and side effects from the cervical preparation will also be evaluated up to 14 days after randomization.

Office Hysteroscopy in Postmenopausal Women: A Randomized Trial of Cervical Preparation Strategies