Androgen profile in Chinese women with polycystic ovary syndrome in their reproductive years.
Zehong Zhou, Rong Li, Jie Qiao
https://pubmed.ncbi.nlm.nih.gov/28684272Actively Recruiting
Age: 0 - 18Years
All Genders
Healthy Volunteers
ID03742011
Health of Offspring Born to Mothers With Polycystic Ovary Syndrome in Guangzhou Cohort Study
Led by Guangzhou Women and Children's Medical Center · Updated on 2024-02-26
2000
Participants Needed
1
Research Sites
678 weeks
Total Duration
On this page
Sponsors
G
Guangzhou Women and Children's Medical Center
Lead Sponsor
U
University of Birmingham
Collaborating Sponsor
AI-Summary
What this Trial Is About
Researchers are investigating the short- and long-term effects of exposure to maternal polycystic ovary syndrome (PCOS) on the health of children born to affected mothers in Guangzhou, China. This observational study explores how conditions like hyperandrogenism and insulin resistance in mothers might influence the offspring's metabolism, endocrine system, and overall health from birth through childhood and adolescence. The study collects detailed data on maternal PCOS subtypes, breastfeeding, diet, and education while monitoring various health outcomes in offspring. Biological samples such as blood and tissue are also gathered. Key health measures include growth parameters, metabolic profiles, neurodevelopment, and reproductive endocrine function assessed at multiple ages from birth to 18 years. Participants will be followed regularly with assessments including laboratory tests for glucolipid metabolism disorders, epigenetic profiling at birth, and intelligence testing at age 6. Weight, height, body fat percentage, intestinal flora, and neurodevelopmental status are tracked at specific intervals up to 18 years old. This long-term study aims to understand how prenatal PCOS exposure impacts health over time.
CONDITIONS
Brief Title
Offspring Born to Mothers With Polycystic Ovary Syndrome in Guangzhou Cohort Study
Who Can Participate
Age: 0 - 18Years
All Genders
Healthy Volunteers
Eligibility Criteria
You may qualify if you...
- Offspring born to women diagnosed with PCOS
- Offspring born to women with less than 20 weeks of gestation, intended to eventually deliver in Guangzhou Women and Children's Medical Center
- Permanent residents or families intended to remain in Guangzhou for at least 3 years
You will not qualify if you...
- None
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
1
2
3
Your Study Journey
Screening
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Diagnostic Evaluation
Duration - From birth to 1 year old
Participants undergo assessments including measurements at birth and during early childhood to evaluate health status and metabolic profiles.
Visits at birth, 6 weeks, 6 months, and 1 year old
Long-term Monitoring
Duration - Up to 18 years
Participants are observed over time to monitor growth, metabolism, neurodevelopment, and other health outcomes.
Periodic visits at ages 3 years, 6 years, 12 years, and 18 years
Trial Site Locations
Total: 1 location
1
Guangzhou Women and Children's Medical Center, China
Guangzhou, Guangdong, China, 510623
Actively Recruiting
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Research Team
X
Xiu Qiu, PhD
Z
Zehong Zhou, MD
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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Published Research Related To This Trial
The Born in Guangzhou Cohort Study (BIGCS).
Xiu Qiu, Jin-Hua Lu, Jian-Rong He...
https://pubmed.ncbi.nlm.nih.gov/28321694