Actively Recruiting
Can Smoking Cessation Improve Physiological Markers of Chronic Pain Risk in Native American Smokers? A Pilot Feasibility Study
Led by University of Oklahoma · Updated on 2026-03-02
150
Participants Needed
1
Research Sites
52 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are evaluating whether 4 weeks of confirmed smoking abstinence after financial incentive treatment can improve physiological markers linked to chronic pain risk in adult Native American smokers. The study focuses on understanding how smoking affects pain amplification and pain inhibition, which are thought to be disrupted in Native Americans who experience high rates of chronic pain. This pilot study aims to assess feasibility and gather data on changes in pain regulation associated with smoking cessation. Participants will receive financial incentives to encourage verified smoking abstinence over a 4-week period. This behavioral intervention includes both short-term and long-term rewards designed to support quitting smoking. The study measures various physiological outcomes before starting treatment and after completing 4 weeks of treatment plus 4 weeks of confirmed abstinence. During the study, participants will undergo assessments of pain inhibition, pain-related spinal reflexes, allostatic load, and pain amplification at baseline (one day before treatment) and after treatment. Secondary outcomes include temporal summation of pain. The study requires participants to own a smartphone with a data plan and be able to communicate in English. Safety and eligibility are carefully monitored, with the total participation spanning the treatment and abstinence verification phases.
CONDITIONS
Brief Title
Oklahoma Study of Native American Pain Risk IV: Smoking Cessation and Pain
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Self-identify as Native American/American Indian
- Currently daily smoker
- Own a smartphone with a data plan
- Ability to speak and read English
You will not qualify if you...
- Younger than 18 years of age
- Currently pregnant
- Self-reported history of heart disease or heart attack
- Angina, arrhythmias, hypertension, heart disease
- Current chronic pain
- Pepper allergy
- Inability to speak English
- Current psychosis (assessed by Psychosis Screening Questionnaire)
- Serious cognitive impairment (assessed by less than 20 score on the Montreal Cognitive Assessment [MoCA])
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 screening and enrollment visit (in-person)
Duration - 4 weeks
Participants undergo a smoking cessation program supported by financial incentives for biochemically verified abstinence.
Weekly visits for 4 weeks (in-person or remote)
Duration - 4 weeks
Participants continue verified smoking abstinence to support sustained behavior change.
Weekly visits for 4 weeks (in-person or remote)
Trial Site Locations
Total: 1 location
1
University of Oklahoma - Schusterman Center
Tulsa, Oklahoma, United States, 74135
Actively Recruiting
Research Team
P
PLAN Lab
J
Jamie L Rhudy, PhD
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
BASIC_SCIENCE
Number of Arms
1
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