Exploring cognitive function and postoperative neurocognitive recovery after cardiac surgery in older adults (ECPON): a protocol for an observational study.
Lina Bergman, Ernad Zecevic, Tor Damén...
https://pubmed.ncbi.nlm.nih.gov/40545303Actively Recruiting
Age: 65Years +
All Genders
ID06469515
Enhanced Continuity of Postoperative Care for Older People in Their Neurocognitive Recovery After Cardiac Surgery
Led by Karolinska Institutet · Updated on 2024-11-07
220
Participants Needed
1
Research Sites
52 weeks
Total Duration
On this page
Sponsors
K
Karolinska Institutet
Lead Sponsor
S
Sahlgrenska University Hospital
Collaborating Sponsor
AI-Summary
What this Trial Is About
Researchers are investigating cognitive function, symptoms, and complaints after cardiac surgery in people aged 65 and older. The study aims to measure the incidence of postoperative cognitive decline, its relationship with factors like delirium and depression, and how it affects daily living and recovery. It also explores the experiences of close relatives during the recovery process. This observational study plans to include 220 participants undergoing planned cardiac surgery and their relatives, following them for six months after surgery. Participants will undergo neurocognitive testing using a digitized battery called Mindmore-P before surgery and at 1, 3, and 6 months afterward. This battery measures verbal memory, attention, executive function, and processing speed. Participants will also be evaluated for postoperative delirium during their hospital stay. Both patients and their relatives will complete questionnaires about symptoms, functional status, fatigue, frailty, quality of life, and caregiver burden. During the study, researchers will assess cognitive changes, depressive symptoms, self-efficacy, and healthcare use. Data will be collected digitally, in person, or at the hospital. Analysis will include comparing cognitive test results to baseline and normative data to identify cognitive decline. Relatives' perspectives on recovery and cognitive function will also be studied. The total participation lasts six months, with repeated assessments to understand recovery patterns and support needs.
CONDITIONS
Brief Title
Older People's Neurocognitive Recovery After Cardiac Surgery
Who Can Participate
Age: 65Years +
All Genders
Eligibility Criteria
You may qualify if you...
- Scheduled for elective or urgent open-heart surgery or minimally invasive cardiac surgery
- Resident in the area/region for the current thoracic clinic
- Able to read and understand Swedish
You will not qualify if you...
- Physical, mental, and cognitive difficulties that prevent the individual from completing the cognitive tests
- Undergone surgery within the last 6 months
AI-Screening
AI-Powered Screening
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Your Study Journey
Screening
Duration - Up to 2 weeks before surgery
Participants are screened for eligibility to participate in the trial.
1 screening and enrollment visit
Diagnostic Evaluation
Duration - Baseline before surgery
Participants undergo baseline neurocognitive testing and assessments before surgery.
1 baseline visit (can be digital, home visit, or hospital visit)
Surgery and Immediate Post-operative Care
Duration - Hospital stay (up to 7 days post-surgery)
Participants undergo cardiac surgery and are monitored for postoperative delirium during the hospital stay.
Delirium assessments twice daily up to postoperative day 7
Post-operative Follow-up
Duration - 6 months after surgery
Participants complete neurocognitive tests and questionnaires to assess cognitive function, symptoms, and quality of life.
Neurocognitive testing and assessments at 1, 3, and 6 months after surgery; weekly cognitive symptom assessments up to 3 months
Trial Site Locations
Total: 1 location
1
Sahlgrenska University Hospital
Gothenburg, Sweden
Actively Recruiting
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Research Team
L
Lina Bergman, PhD
U
Ulrica Nilsson, Professor
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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