Using Optical Coherence Tomography to Guide Treatment of Intracranial Atherosclerotic Stenosis A Prospective Study Evaluating Vessel Wall Structure and Stroke Risk

What this Trial Is About

Researchers are evaluating the clinical significance of optical coherence tomography OCT in treating intracranial atherosclerotic stenosis ICAS, a condition linked to ischemic stroke. ICAS accounts for a significant portion of stroke cases, especially in Asia, and understanding the characteristics of atheromatous plaques may help predict stroke risk and guide treatment. This study aims to improve insight into how OCT can evaluate vessel wall structure to better guide interventional therapy and correlate plaque features with clinical and biological information. Participants will undergo OCT and classical imaging evaluations like Transcranial Color Doppler TCCD and high-resolution MRI. Based on OCT findings, tailored treatments such as antithrombotic management or post-dilation may be applied if specific plaque characteristics are observed. Another group will receive standard imaging followed by percutaneous transluminal angioplasty and stenting without OCT guidance. Throughout the study, researchers will monitor participants for safety outcomes including death or stroke within 30 days of enrollment. Longer-term outcomes such as death, stroke recurrence, restenosis, and dependency will be assessed at one year. Medical imaging, clinical evaluations, and biological data will be collected to understand treatment effects and plaque characteristics during the study period ending in 2027.

Optical Coherence Tomography for Intracranial Atherosclerotic Stenosis