Actively Recruiting
Optimization of the Skin Test Procedure With Iodinated Contrast Products for Certain Patients Suspected of Immediate Hypersensitivity
Led by University Hospital, Strasbourg, France · Updated on 2024-07-12
100
Participants Needed
1
Research Sites
4 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Hypersensitivity to iodinated contrast products (ICPs) affects 1 to 3% of patients who receive these injections. To identify whether reactions are caused by allergic immune responses or other mechanisms, allergological assessments using skin tests are needed. Current guidelines recommend performing prick tests followed by intradermal reactions up to a tenth dilution, but some teams use undiluted intradermal reactions (IDRs) under specific conditions without formal validation. Experience suggests that undiluted IDRs may be useful for diagnosis in certain patients without added risk. This observational study reviews past patient records to evaluate the relevance of performing pure intradermal reactions with undiluted ICPs after a negative prick test. The data analyzed cover patients treated from June 1, 2020, to July 3, 2023, who underwent at least one undiluted intradermal reaction test for suspected immediate hypersensitivity to ICPs. No new treatments or interventions are administered as part of this study. Participants are adults aged 18 and older who have been treated in the allergology department for suspected allergic reactions to ICPs. Their medical data are reviewed retrospectively to assess the diagnostic value of the undiluted intradermal tests. The main outcome measured is the relevance of performing these skin tests following a negative prick test. Participants' data are included only if there is no written opposition to reuse for scientific research. The study is led by the University Hospital in Strasbourg, France.
CONDITIONS
Brief Title
Optimization of the Skin Test Procedure With Iodinated Contrast Products for Certain Patients Suspected of Immediate Hypersensitivity
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18 years or older
- Treated in the allergology department between June 1, 2020 and July 3, 2023 for suspected allergic hypersensitivity to iodinated contrast products
- Had at least one undiluted intradermal skin test to one or more iodinated contrast products
- No written opposition to reuse of medical data for scientific research in the medical file
You will not qualify if you...
- Presence of opposition to reuse of medical data for scientific research
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
Duration - Retrospective over 3 years
Participants undergo skin testing procedures with iodinated contrast products to assess hypersensitivity.
Trial Site Locations
Total: 1 location
1
Service de Pneumologie - CHU de Strasbourg - France
Strasbourg, France, 67091
Actively Recruiting
Research Team
C
Carine METZ-FAVRE, MD
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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