Actively Recruiting

Phase Not Applicable
Age: 65Years +
All Genders
ID06951620

Optimizing Aerobic Fitness and Functional Response to Exercise in Older Adults

Led by University of Vermont Medical Center · Updated on 2025-06-08

114

Participants Needed

1

Research Sites

15 weeks

Total Duration

On this page

Sponsors

U

University of Vermont Medical Center

Lead Sponsor

N

National Institute on Aging (NIA)

Collaborating Sponsor

AI-Summary

What this Trial Is About

Cardiovascular disease often leads to hospitalization and disability in older adults. This research aims to improve recovery of aerobic fitness and physical function in older cardiac patients by comparing a new high intensity training program with the traditional moderate intensity cardiac rehabilitation exercises. The study focuses on older adults who have experienced recent heart events like myocardial infarction or percutaneous interventions, seeking better ways to reduce disability and improve health outcomes. Participants will be randomly assigned to one of two exercise programs: a combined high intensity interval aerobic training (HIIT) with high intensity resistance training (HIRT), or the usual moderate intensity continuous aerobic training (MICT) with moderate intensity resistance training (MIRT) used in cardiac rehabilitation. Both approaches are performed during Phase 2 cardiac rehabilitation following hospitalization. The study compares these two regimens to see which better improves aerobic capacity and physical function. During the study, participants’ aerobic fitness and physical function will be measured within four months after starting the exercise program. Tests include the 30-second sit-to-stand test and assessments of quality of life, depressive symptoms, executive function, physical function through a six-minute walk test, enjoyment of exercise, and anxiety. The study involves regular monitoring and safety assessments throughout to evaluate the effects of the training on participants’ recovery and functional abilities.

CONDITIONS

Brief Title

Optimizing Aerobic Fitness in Older Adults

Who Can Participate

Age: 65Years +
All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • Age 65 years or older
  • Able to walk and move around independently
  • Enrolled in cardiac rehabilitation at the study center following a recent diagnosis of myocardial infarction or percutaneous intervention
Not Eligible

You will not qualify if you...

  • Active malignancy (except non-melanoma skin cancer or low grade prostate cancer under surveillance)
  • Unwilling to comply with the assigned exercise program
  • Submaximal exercise test performance with respiratory exchange ratio less than 1.0 at study entry

AI-Screening

AI-Powered Screening

Complete this quick 3-step screening to check your eligibility

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Your Study Journey

Screening

Duration - 2 to 4 weeks

Participants are screened for eligibility to participate in the trial.

1 visit (in-person)

Treatment

Duration - Up to 4 months

Participants receive either high intensity interval training combined with high intensity resistance training (HIIT+HIRT) or moderate intensity continuous aerobic training combined with moderate intensity resistance training (MICT+MIRT) as part of Phase 2 Cardiac Rehabilitation to improve aerobic fitness and physical function.

Visits as part of cardiac rehabilitation sessions over the treatment period

Trial Site Locations

Total: 1 location

1

UVMMC Cardiac Rehabilitation

South Burlington, Vermont, United States, 05403

Actively Recruiting

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Research Team

P

Patrick Savage, Research Coordinator

How is the study designed?

Study Type

INTERVENTIONAL

Masking

TRIPLE

Allocation

RANDOMIZED

Model

PARALLEL

Primary Purpose

TREATMENT

Number of Arms

2

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