Actively Recruiting
Optimizing Aerobic Fitness and Functional Response to Exercise in Older Adults
Led by University of Vermont Medical Center · Updated on 2025-06-08
114
Participants Needed
1
Research Sites
15 weeks
Total Duration
On this page
Sponsors
U
University of Vermont Medical Center
Lead Sponsor
N
National Institute on Aging (NIA)
Collaborating Sponsor
AI-Summary
What this Trial Is About
Cardiovascular disease often leads to hospitalization and disability in older adults. This research aims to improve recovery of aerobic fitness and physical function in older cardiac patients by comparing a new high intensity training program with the traditional moderate intensity cardiac rehabilitation exercises. The study focuses on older adults who have experienced recent heart events like myocardial infarction or percutaneous interventions, seeking better ways to reduce disability and improve health outcomes. Participants will be randomly assigned to one of two exercise programs: a combined high intensity interval aerobic training (HIIT) with high intensity resistance training (HIRT), or the usual moderate intensity continuous aerobic training (MICT) with moderate intensity resistance training (MIRT) used in cardiac rehabilitation. Both approaches are performed during Phase 2 cardiac rehabilitation following hospitalization. The study compares these two regimens to see which better improves aerobic capacity and physical function. During the study, participants’ aerobic fitness and physical function will be measured within four months after starting the exercise program. Tests include the 30-second sit-to-stand test and assessments of quality of life, depressive symptoms, executive function, physical function through a six-minute walk test, enjoyment of exercise, and anxiety. The study involves regular monitoring and safety assessments throughout to evaluate the effects of the training on participants’ recovery and functional abilities.
CONDITIONS
Brief Title
Optimizing Aerobic Fitness in Older Adults
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 65 years or older
- Able to walk and move around independently
- Enrolled in cardiac rehabilitation at the study center following a recent diagnosis of myocardial infarction or percutaneous intervention
You will not qualify if you...
- Active malignancy (except non-melanoma skin cancer or low grade prostate cancer under surveillance)
- Unwilling to comply with the assigned exercise program
- Submaximal exercise test performance with respiratory exchange ratio less than 1.0 at study entry
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Up to 4 months
Participants receive either high intensity interval training combined with high intensity resistance training (HIIT+HIRT) or moderate intensity continuous aerobic training combined with moderate intensity resistance training (MICT+MIRT) as part of Phase 2 Cardiac Rehabilitation to improve aerobic fitness and physical function.
Visits as part of cardiac rehabilitation sessions over the treatment period
Trial Site Locations
Total: 1 location
1
UVMMC Cardiac Rehabilitation
South Burlington, Vermont, United States, 05403
Actively Recruiting
Research Team
P
Patrick Savage, Research Coordinator
How is the study designed?
Study Type
INTERVENTIONAL
Masking
TRIPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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