Oral Health and Wilson's Disease: SOMAWI

What this Trial Is About

This research focuses on patients with Wilson disease, a condition affecting copper metabolism, and aims to compare oral health between those with hepatic and neurological forms of the disease and a control group without Wilson disease. It highlights that patients with Wilson disease often have poorer dental and periodontal health and a lower oral quality of life. Neurological patients may have more difficulty with jaw function, and treatments for Wilson disease can cause oral mucosa lesions. The study is observational and involves patients and controls undergoing dental health assessments. Participants include patients diagnosed with Wilson disease in either hepatic or neurological forms, as well as control individuals attending routine dental consultations outside emergency or treatment follow-up contexts. The study evaluates dental health using the CAOD index, which measures the severity of caries by counting decayed, absent, and filled permanent teeth. Data collection involves clinical dental exams, panoramic dental imaging, saliva sample collection, and an oral quality of life questionnaire called OHIP-14. During the study, participants undergo a detailed dental examination and provide saliva samples to assess copper levels, which may indicate treatment effectiveness. Controls complete the same oral exams and questionnaires to allow comparison. The primary outcome is the CAOD index score measured at the inclusion visit. The study monitors oral health differences among groups to better understand the impact of Wilson disease on dental conditions. Participation involves one visit with clinical, imaging, and questionnaire assessments.

Oral Health and Wilson's Disease: SOMAWI