Actively Recruiting
Oral Melatonin Versus Oral Pregabalin on Postoperative Pain and Anxiety Following Spine Surgery
Led by Tanta University · Updated on 2026-01-21
105
Participants Needed
1
Research Sites
71 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This study aims to compare the efficacy of using Melatonin versus Pregabalin on postoperative pain and anxiety after spine surgeries.
CONDITIONS
Official Title
Oral Melatonin Versus Oral Pregabalin on Postoperative Pain and Anxiety Following Spine Surgery
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients aged 21-60 years old
- Both sexes
- Patients of American Society of Anesthesiologists (ASA) physical status I & II
- Undergoing elective spine surgery
You will not qualify if you...
- Patient refusal
- History of allergic reactions to melatonin or pregabalin
- Patients with cardiovascular disease (ischemic heart disease, Heart Failure, Arrythmia, Heart Block)
- Patients with kidney disease with (plasma creatinine level > 1.5mg/dl)
- Patients with liver disease with (aspartate transaminase, alanine transaminase, and bilirubin levels more than twice the upper limit of normal)
- Psychological and cognitive disorders; dementia; major depression
- Circadian rhythm disorders such as chronic fatigue syndrome and drowsiness
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Tanta University
Tanta, El-Gharbia, Egypt, 31527
Actively Recruiting
Research Team
A
Ahmed H Ayad, MSc
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
3
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