Comparing Oral Melatonin and Pregabalin for Pain and Anxiety Relief After Spine Surgery in Adults Aged 21 to 60

What this Trial Is About

Researchers are evaluating how oral melatonin compares to oral pregabalin for managing pain and anxiety after spine surgery. This trial focuses on adults aged 21 to 60 undergoing elective spine surgery and explores relief during the critical first few days after surgery. Melatonin is a natural hormone with effects on sleep, pain, and anxiety, while pregabalin is a medication that affects nerve signals to reduce pain sensations. Participants are randomly assigned to one of three groups a placebo group receiving inactive capsules, a melatonin group receiving 5 mg melatonin capsules at specified times, and a pregabalin group receiving 75 mg pregabalin capsules. The dosing schedule includes capsules the evening before surgery, two hours prior to surgery, and then twice daily for three days after surgery. The study uses a double-blind design to ensure unbiased results. During the study, participants will be monitored for pain levels, anxiety, analgesic use, and sleep quality for three days after surgery. Researchers will collect data on these outcomes to compare the effects of melatonin and pregabalin. The trial is sponsored by Tanta University and is planned to run until June 2027, with participants undergoing assessments throughout the postoperative period to evaluate the treatments impact.

Oral Melatonin Versus Oral Pregabalin on Postoperative Pain and Anxiety Following Spine Surgery