Effect of Inspiratory Muscle Training on Fatigue and Lung Function in Adolescents with Familial Mediterranean Fever

What this Trial Is About

This research focuses on adolescents aged 13 to 17 years with Familial Mediterranean Fever FMF, a condition often diagnosed before age 18 and associated with reduced exercise tolerance, lung function, and fatigue tolerance. The study aims to evaluate the effects of inspiratory muscle retraining IMR on these symptoms in FMF adolescents. Participants will be randomly assigned to one of two groups the IMR group or a control group. The IMR group will perform two inspiratory muscle retraining sessions daily, five days a week, for eight weeks. Each session includes three sets of training, with each set consisting of 10 breath cycles. Both groups will continue their prescribed daily colchicine medication throughout the eight-week period. During the study, researchers will assess fatigue levels using the Multidimensional Scale of Fatigue from the pediatric quality of life questionnaire after eight weeks. Additional measurements will include walking distance over six minutes, lung function tests, maximum inhalation pressure, and physical and mental health scores. The total participation duration is eight weeks, with evaluations conducted at the end of this period.

Outcomes of Inspiratory Muscle Training in FMF Adolescents