Profound neuronal differences during exercise-induced hypoalgesia between athletes and non-athletes revealed by functional near-infrared spectroscopy.
Maria Geisler, Marco Herbsleb, Feliberto de la Cruz...
https://pubmed.ncbi.nlm.nih.gov/41749046/Actively Recruiting
Led by Marquette University · Updated on 2026-03-31
90
Participants Needed
1
Research Sites
N/A
Total Duration
Researchers are studying how pain is experienced and influenced by moderate-intensity exercise in midlife adults aged 35 to 65. The study compares three groups former competitive athletes who no longer participate in sports, current masters athletes actively engaged in training, and nonathletes. The goal is to understand pain processing and lifestyle behaviors among these groups, considering sex differences and physical activity history. Participants undergo three testing sessions including baseline assessments of strength, fitness, and pain. They then complete two exercise interventionsmoderate-intensity strength training and aerobic exercisein a randomized order with at least one week washout between sessions. Strength exercise involves isometric knee extensions, while aerobic exercise consists of treadmill walking at 40-59% heart rate reserve. Pain and exertion ratings are collected before, during, and after exercises. Throughout the study, participants wear physical activity monitors and an OURA ring to track movement and sleep over about two weeks. Pain tolerance, pressure pain threshold, and other sensory pain measures are taken at baseline and before and after exercise sessions. Researchers also monitor step counts, sedentary behavior, and sleep duration. The total participation includes baseline and two follow-up sessions approximately one week apart, allowing detailed evaluation of pain responses to different exercise types.
CONDITIONS
Pain in Aging Former Athletes, Master's Athletes, and Nonathletes
J
Jacob J Capin, DPT, PhD
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here
Marquette University
Lead Sponsor
This table compares participation in this trial with other options available for this condition. The information is drawn from published research and the trial’s study details and is provided for educational purposes only.
| Factors | Former Competitive Athletes | Master's Athletes | Nonathlete Controls |
|---|---|---|---|
| What it is | Adults aged 35–65 who previously competed at national (Tier 3) or higher sporting levels, but have not been actively involved in competitive or recreational sport in the past five years. Participants perform moderate-intensity strength and aerobic exercise for study assessments. | Adults aged 35–65 who are currently participating in competitive sports (Tier 2 or higher) with dedicated training at least three times per week. Participants complete both moderate-intensity strength and aerobic exercise interventions as part of the study. | Adults aged 35–65 who have not participated in competitive sport at a national level or higher and who are not currently taking part in competitive sports. They act as controls, taking part in the same exercise and pain measurement activities. |
| Role in trial | Evaluated for how a legacy of high-level athletic activity influences pain, exercise tolerance, and recovery. | Assessed to see how ongoing athletic competition and regular training affect pain processing and exercise responses. | Serves as the control group to identify differences linked to athletic background in pain and physical activity outcomes. |
| Primary use or focus | To assess pain thresholds, pain tolerance, and responses to both strength and aerobic exercise after an extensive period away from organized sport. | Evaluates how regular, ongoing sport training impacts measures of pain sensitivity, activity levels, and post-exercise recovery. | Used as a benchmark to understand pain and activity differences compared to the two athlete cohorts. |
| How exercise is performed or measured | Participants perform 10 isometric knee extensions at 50% maximal contraction, with pain ratings and exertion measured, and also complete 30 minutes of moderate treadmill walking (40–59% heart rate reserve). Pre- and post-exercise pain thresholds and exertion are evaluated. | Completes the same strength (isometric knee extension) and aerobic (treadmill walking at target intensity) interventions with identical testing and measurements, including Quantitative Sensory Testing before and after exercise. | Undergoes the same sequence of moderate-intensity strength and aerobic exercise, pain and exertion measurement, and sensory testing as the athlete groups. |
| Published evidence status | Long-term outcomes and quality of life for former athletes can vary: some studies show higher risk for joint pain or osteoarthritis while others suggest comparable or better overall health metrics than nonathletes. However, pain response during exercise in this midlife group is not yet fully established. | Regular ongoing sports participation in midlife is associated with increased pain tolerance and favorable health outcomes compared to inactive peers or former athletes. Active Master's athletes may have lower pain sensitivity during and after exercise. | Nonathletes tend to have lower pain tolerance and may report higher pain levels during exercise compared to age-matched athletic peers. Regular exercise training can modulate pain threshold and sensation. |
| Important study limitations and research gaps | Former athletes may differ in underlying injuries, past training intensity, and time since last competition, which could influence results. Most evidence is cross-sectional or survey-based rather than interventional. | These findings may not apply to all types of athletic training or to individuals with significant musculoskeletal injury. Data come mostly from observational comparisons rather than large randomized interventions. | Nonathlete controls may differ in physical activity, pain history, and broader health status unrelated to sport, affecting findings. Representative baseline health varies. |
Disclaimer: This comparison is created with the help of artificial intelligence(AI) and may contain errors or missing information. It is not medical advice and does not mean one option is better or safer than another. Clinical trials are still being studied, and joining a trial is your choice. Please consult your healthcare professional before making any decisions.
You may qualify if you...
You will not qualify if you...
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - 1 day
Participants complete baseline testing including quantitative sensory testing and questionnaires, and begin wearing a physical activity monitor and an OURA ring for lifestyle behavior monitoring.
1 baseline visit (in-person)
Duration - Approximately 2 weeks
Participants complete two separate moderate-intensity exercise interventions (strength and aerobic) in randomized order to assess pain response to exercise.
2 intervention visits spaced about 1 week apart (in-person)
Duration - 2 to 3 weeks
Participants wear activity monitors to assess physical activity, sedentary behavior, and sleep for approximately 2 to 3 weeks throughout the study.
Remote monitoring with wearable devices
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
CROSSOVER
Primary Purpose
TREATMENT
Number of Arms
3
Have more questions? Get in touch with our team for quick support
Maria Geisler, Marco Herbsleb, Feliberto de la Cruz...
https://pubmed.ncbi.nlm.nih.gov/41749046/Thomas L Schwenk, Daniel W Gorenflo, Richard R Dopp...
https://pubmed.ncbi.nlm.nih.gov/17414796/Jena Heck Street, Abigail M Larson, Roman de Guia...
https://pubmed.ncbi.nlm.nih.gov/41572326/Abigail Larson, Jena Heck Street, Roman de Guia...
https://pubmed.ncbi.nlm.nih.gov/41675555/Victor J Dzau, Philip A Pizzo
https://pubmed.ncbi.nlm.nih.gov/25321905/S Drawer, C W Fuller
https://pubmed.ncbi.nlm.nih.gov/11726474/Jena Heck Street, Zebadiah P Boos, Alissa Fial...
https://pubmed.ncbi.nlm.nih.gov/37920279/Jacob John Capin, Taylor L Wolf, Jena Heck Street...
https://pubmed.ncbi.nlm.nih.gov/38736641/Alannah K A McKay, Trent Stellingwerff, Ella S Smith...
https://pubmed.ncbi.nlm.nih.gov/34965513/Janet E Simon, Mallory Lorence, Carrie L Docherty
https://pubmed.ncbi.nlm.nih.gov/33150419/Marquette University
Lead Sponsor