Actively Recruiting
Personalized Radiotherapy for Individualized Treatment Strategies and Monitoring (PRISM)
Led by University of Texas Southwestern Medical Center · Updated on 2025-11-10
45
Participants Needed
1
Research Sites
252 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
To characterize feasibility, safety, and/or preliminary efficacy of personalized strategies to adapt standard radiotherapy treatments to individual patient responses.
CONDITIONS
Official Title
Personalized Radiotherapy for Individualized Treatment Strategies and Monitoring (PRISM)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- 18 years or older
- Performance status ECOG 0-2
- Extensive stage small cell lung cancer diagnosed by tissue biopsy within 180 days of registration (Cohort A)
- Planned for or receiving standard chemoimmunotherapy
- Received no more than 3 cycles of chemoimmunotherapy by enrollment
- Able and indicated to receive thoracic radiotherapy (Cohort A)
- Diagnosis of solid tumor malignancy with 1-5 MRI-defined brain metastasis lesions within 60 days of registration (Cohort B)
- Brain metastases sized 2-5 cm, or 1.5-5 cm if in brainstem (Cohort B)
You will not qualify if you...
- Prior thoracic radiotherapy (Cohort A)
- Prior whole brain radiotherapy (Cohort B)
- Prior surgical resection or focal radiotherapy of a target brain metastasis (Cohort B)
- Leptomeningeal disease (Cohort B)
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Ut Southwestern Medical Center
Dallas, Texas, United States, 75390
Actively Recruiting
Research Team
S
SARAH NEUFELD
CONTACT
N
NEIL DESAI, MD, MHS
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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