Study of Genetic and Physical Traits in Adults with Type 2 Diabetes and Severe Obesity in Greenland Including Sleep Apnea Assessment and Personalized Treatment Options

What this Trial Is About

Researchers are studying the phenotypic and genotypic characteristics of people living with type 2 diabetes and severe obesity in Greenland, focusing on how genetic factors influence disease development and complications. The study also explores the prevalence of obstructive sleep apnea OSA in this population and aims to develop personalized medicine approaches based on genotype, especially concerning MODY diabetes and metabolic disorders. Participants will undergo whole genome sequencing to identify genetic variants linked to diabetes and insulin resistance. They will be examined for diabetic complications and sleep apnea using devices like the VAGUS handheld device for cardiovascular autonomic neuropathy and the NightOwl device for sleep apnea monitoring over three nights. Those diagnosed with severe sleep apnea may receive continuous positive airway pressure CPAP treatment. During the study, participants will complete questionnaires on quality of life and daytime sleepiness and undergo clinical measurements of body size and airway features. Blood samples will be collected for genetic testing. The research team will track diabetic complications, sleep apnea presence, and CPAP treatment compliance and effects over six months. The study provides detailed health assessments without randomizing treatment but offers appropriate care when criteria are met.

Phenotypic and Genotypic Characterization of Patients With Dysmetabolism in Greenland