NCCN Guidelines Insights: Non-Small Cell Lung Cancer, Version 1.2020.
David S Ettinger, Douglas E Wood, Charu Aggarwal...
https://pubmed.ncbi.nlm.nih.gov/31805526/Actively Recruiting
Led by University of Utah · Updated on 2026-02-03
20
Participants Needed
2
Research Sites
204 weeks
Total Duration
Researchers are evaluating the feasibility of a precision exercise program called the Precision Exercise Regimen for Cancer Care PERCC for patients with stage II and stage III Non-Small Cell Lung Cancer NSCLC who are undergoing multimodal therapy. This pilot study focuses on whether this exercise program can be successfully implemented through telehealth for lung cancer patients receiving treatments at the University of Utahs Huntsman Cancer Institute. The PERCC program is a home-based exercise intervention supervised virtually. Participants will start exercising at least two weeks before their first neoadjuvant treatment and continue until two months after surgery. The exercises include mobility activities, aerobic, and resistance training performed in various positions such as lying down, sitting, standing, and walking. Each week, participants will have one supervised exercise session via telehealth focusing on resistance exercises, while aerobic exercises will be done individually without supervision. Throughout the study, participants will be monitored from the pre-treatment visit until about two months post-surgery. Researchers will assess recruitment and retention feasibility as the primary outcome, and safety as a secondary outcome during this period. Participants will complete questionnaires and follow the exercise program as prescribed, enabling study staff to evaluate how well the program can be delivered and maintained in this patient population.
CONDITIONS
PILOT for The Precision Exercise Regimen for Cancer Care (PERCC) Study
T
Thomas Varghese, MD, MS, MBA, FACS
C
Cornelia Ulrich, MS, PhD
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University of Utah
Lead Sponsor
This table compares participation in this trial with other options available for this condition. The information is drawn from published research and the trial’s study details and is provided for educational purposes only.
| Factors | Investigational PERCC Exercise Program | Guideline-Recommended Perioperative Rehabilitation |
|---|---|---|
| What is it? | A structured, multimodal exercise regimen delivered via telehealth (1 supervised session per week focusing on resistance exercises plus unsupervised aerobic sessions) for patients with stage II/III NSCLC undergoing perioperative multimodality treatment. | A combination of supervised exercise, physical therapy, and patient counseling on physical activity before and after lung cancer surgery, as recommended by major guidelines for patients undergoing resection and perioperative therapy. |
| Role in study | The only intervention tested, delivered alongside planned multimodality cancer therapy (chemotherapy or immunotherapy and surgery). Study will evaluate its feasibility and safety. | Serves as the recommended standard approach to optimizing fitness and supporting recovery before and after lung cancer surgery, usually applied in clinical care. |
| Primary use or purpose | To assess whether a home-based, supervised exercise regimen is feasible and safe for people with stage II/III NSCLC during multimodality therapy and surgery. | To enhance patients’ physical function, reduce postoperative complications, and support recovery before and after lung cancer surgery. |
| How is it given/performed? | Participants attend one weekly supervised exercise session via telehealth, focusing on resistance training. Additional unsupervised aerobic sessions are completed individually at home. Exercises include mobility, calisthenics, aerobic, and resistance modes in various postures. | Guidelines recommend supervised or semi-supervised exercise programs (in-clinic or at-home) tailored to individual needs, including aerobic and resistance training, with regular follow-up by the care team. |
| What is the current evidence status? | Currently being studied; results for feasibility and safety are not yet established and no published outcomes are available from this trial. | Strong evidence from multiple studies and guidelines supports that perioperative exercise or rehabilitation improves physical outcomes and recovery in lung cancer surgery. |
| Important limitations | Small pilot study, not powered to assess clinical outcomes. Feasibility results may not generalize to wider populations. Final benefits or risks are unknown until full results are available. | Access to supervised rehabilitation varies; not all patients can receive structured sessions. Patient fitness and treatment plans may limit participation. |
Disclaimer: This comparison is created with the help of artificial intelligence(AI) and may contain errors or missing information. It is not medical advice and does not mean one option is better or safer than another. Clinical trials are still being studied, and joining a trial is your choice. Please consult your healthcare professional before making any decisions.
You may qualify if you...
You will not qualify if you...
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
screening and enrollment visit
Duration - Starting at least two weeks before neoadjuvant treatment and continuing until two months after surgery
Participants engage in the Precision Exercise Regimen for Cancer Care (PERCC), a virtually supervised home-based exercise program. This includes one supervised exercise session per week via telehealth focusing on resistance exercises, and additional unsupervised aerobic exercise sessions performed individually.
Weekly supervised exercise sessions via telehealth
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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https://pubmed.ncbi.nlm.nih.gov/35469182/University of Utah
Lead Sponsor