Actively Recruiting

All Genders
ID06501287

Postprandial Triglyceride Impact on Coronary Atherosclerosis in Non-Diabetic Patients at Sohag University Hospital

Led by Fatma Madhy Eissa · Updated on 2024-07-15

160

Participants Needed

1

Research Sites

N/A

Total Duration

On this page

AI-Summary

What this Trial Is About

Coronary artery disease (CAD) is a leading cause of death worldwide, caused by the buildup of fats and inflammatory cells in the arteries, a process called atherosclerosis. This condition is closely linked to lipid levels in the blood, including cholesterol and triglycerides. This research focuses on how the rise in triglyceride levels after eating, called postprandial triglycerides, may influence the development of coronary atherosclerosis in patients without diabetes. The study observes patients with different coronary artery conditions based on angiography results and postprandial triglyceride levels. Participants are placed into groups: those with normal coronary arteries and triglycerides, those with abnormal arteries and high triglycerides above 200 mg/dL, and those with abnormal arteries but normal triglycerides. The severity of coronary artery disease in affected patients is further classified by a scoring system. The study uses diagnostic tests to measure the impact of postprandial triglycerides on coronary atherosclerosis. During the seven-month study period, researchers monitor postprandial triglyceride levels and coronary artery conditions using laboratory tests, ECG, and angiography. They assess the relationship between triglyceride levels after meals and the severity of coronary artery disease. Participants undergo regular evaluations to track these measurements, helping researchers understand the role of triglycerides in coronary atherosclerosis progression in non-diabetic patients.

CONDITIONS

Brief Title

Postprandial Triglyceride Impact on Coronary Atherosclerosis in Non-Diabetic Patient in Sohag University Hospital

Who Can Participate

All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • Diagnosis of coronary artery disease based on coronary angiography, laboratory tests, and ECG evidence
Not Eligible

You will not qualify if you...

  • Presence of liver disorders
  • Presence of kidney disorders
  • Presence of thyroid diseases
  • Diagnosis of diabetes

AI-Screening

AI-Powered Screening

Complete this quick 3-step screening to check your eligibility

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Your Study Journey

Screening

Duration - 2 to 4 weeks

Participants are screened for eligibility to participate in the trial.

1 visit (in-person)

Diagnostic Evaluation

Duration - Single assessment

Participants undergo diagnostic tests to assess postprandial triglyceride levels and coronary artery status.

1 visit (in-person)

Long-term Monitoring

Duration - 7 months

Participants are monitored over 7 months to observe the impact of postprandial triglyceride levels on coronary atherosclerosis.

Periodic visits depending on group assignment

Trial Site Locations

Total: 1 location

1

Sohag university Hospital

Sohag, Egypt

Actively Recruiting

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Research Team

F

Fatma M Eissa, resident

A

Ali M kassem, professor

How is the study designed?

Study Type

OBSERVATIONAL

Masking

N/A

Allocation

N/A

Model

N/A

Primary Purpose

N/A

Number of Arms

3

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Published Research Related To This Trial

2018 AHA/ACC/AACVPR/AAPA/ABC/ACPM/ADA/AGS/APhA/ASPC/NLA/PCNA Guideline on the Management of Blood Cholesterol: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines.

Scott M Grundy, Neil J Stone, Alison L Bailey...

https://pubmed.ncbi.nlm.nih.gov/30586774

Nonfasting triglycerides and risk of myocardial infarction, ischemic heart disease, and death in men and women.

Børge G Nordestgaard, Marianne Benn, Peter Schnohr...

https://pubmed.ncbi.nlm.nih.gov/17635890

Two consecutive high-fat meals affect endothelial-dependent vasodilation, oxidative stress and cellular microparticles in healthy men.

M E Tushuizen, R Nieuwland, P G Scheffer...

https://pubmed.ncbi.nlm.nih.gov/16689751