Actively Recruiting

Phase 4
Age: 75Years +
All Genders
Healthy Volunteers
NCT04262206

Pragmatic Evaluation of Events And Benefits of Lipid-lowering in Older Adults

Led by Duke University · Updated on 2025-11-05

20000

Participants Needed

103

Research Sites

330 weeks

Total Duration

On this page

Sponsors

D

Duke University

Lead Sponsor

N

National Institute on Aging (NIA)

Collaborating Sponsor

AI-Summary

What this Trial Is About

PREVENTABLE is a multi-center, randomized, parallel group, placebo-controlled superiority study. Participants will be randomized 1:1 to atorvastatin 40 mg or placebo. This large study conducted in community-dwelling older adults without cardiovascular disease (CVD) or dementia will demonstrate the benefit of statins for reducing the primary composite of death, dementia, and persistent disability and secondary composites including mild cognitive impairment (MCI) and cardiovascular events.

CONDITIONS

Official Title

Pragmatic Evaluation of Events And Benefits of Lipid-lowering in Older Adults

Who Can Participate

Age: 75Years +
All Genders
Healthy Volunteers

Eligibility Criteria

Eligible

You may qualify if you...

  • Community-dwelling adults
  • Age 6475 years
  • English or Spanish as primary language
  • Able to provide a trusted contact
Not Eligible

You will not qualify if you...

  • Clinically evident cardiovascular disease, including prior heart attack, stroke, revascularization, or statin use for secondary prevention
  • Hospitalization for heart failure in the past 12 months
  • Diagnosed or clinically evident dementia
  • Dependence in any basic daily living activities, except urinary or bowel continence
  • Severe hearing impairment preventing phone follow-up
  • Unable to talk, preventing phone follow-up
  • Statin use in the past year or for longer than 5 years previously
  • Ineligibility to take atorvastatin 40 mg as determined by a clinician
  • Documented intolerance to statins
  • Active liver disease

AI-Screening

AI-Powered Screening

Complete this quick 3-step screening to check your eligibility

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Trial Site Locations

Total: 103 locations

1

University of Alabama at Birmingham

Birmingham, Alabama, United States, 35205

Actively Recruiting

2

Birmingham VA

Birmingham, Alabama, United States, 35233

Actively Recruiting

3

Southern Arizona VA Health Care System - Tucson

Tucson, Arizona, United States, 85723

Actively Recruiting

4

Little Rock VA Medical Center

Little Rock, Arkansas, United States, 72114

Actively Recruiting

5

University of Arkansas for Medical Sciences

Little Rock, Arkansas, United States, 72204

Actively Recruiting

6

Fresno VA Medical Center

Fresno, California, United States, 93703

Actively Recruiting

7

Long Beach VA Medical Center

Long Beach, California, United States, 90822

Actively Recruiting

8

Cedars-Sinai Medical Center

Los Angeles, California, United States, 90048

Not Yet Recruiting

9

VA Greater Los Angeles

Los Angeles, California, United States, 90073

Actively Recruiting

10

VA Palo Alto Healthcare System

Palo Alto, California, United States, 94550

Withdrawn

11

VA San Diego Medical Center

San Diego, California, United States, 92161

Actively Recruiting

12

Yale University

New Haven, Connecticut, United States, 06520

Actively Recruiting

13

VA Connecticut Healthcare System

West Haven, Connecticut, United States, 006111

Actively Recruiting

14

Bay Pines VA

Bay Pines, Florida, United States, 33744

Actively Recruiting

15

Gainesville VA Medical Center

Gainesville, Florida, United States, 32608

Actively Recruiting

16

University of Florida

Gainesville, Florida, United States, 32610

Actively Recruiting

17

University of Florida

Jacksonville, Florida, United States, 32608

Actively Recruiting

18

Miami VA Medical Center

Miami, Florida, United States, 33125

Actively Recruiting

19

University of Miami

Miami, Florida, United States, 33136

Actively Recruiting

20

Atlanta VA Medical Center

Atlanta, Georgia, United States, 30033

Actively Recruiting

21

Emory University

Atlanta, Georgia, United States, 30322

Actively Recruiting

22

Northwestern University

Chicago, Illinois, United States, 60208

Actively Recruiting

23

University of Illinois at Chicago

Chicago, Illinois, United States, 60608

Actively Recruiting

24

Chicago VA Medical Center/Jesse Brown VA

Chicago, Illinois, United States, 60612

Withdrawn

25

Rush University Medical Center

Chicago, Illinois, United States, 60612

Actively Recruiting

26

University of Chicago

Chicago, Illinois, United States, 60637

Actively Recruiting

27

Hines VA Medical Center

Hines, Illinois, United States, 60141

Actively Recruiting

28

North Chicago VA Medical Center

North Chicago, Illinois, United States, 60064

Actively Recruiting

29

Indianapolis VA Medical Center

Indianapolis, Indiana, United States, 46202

Actively Recruiting

30

University of Iowa Healthcare

Iowa City, Iowa, United States, 52242

Actively Recruiting

31

Kansas City VA Medical Center

Kansas City, Kansas, United States, 64128

Actively Recruiting

32

University of Kansas Medical Center

Kansas City, Kansas, United States, 66160

Actively Recruiting

33

VA Eastern Kansas Healthcare System

Topeka, Kansas, United States, 66622

Not Yet Recruiting

34

Louisville VA Medical Center

Louisville, Kentucky, United States, 40206

Actively Recruiting

35

University Medical Center

New Orleans, Louisiana, United States, 70112

Completed

36

Ochsner Clinic Foundation

New Orleans, Louisiana, United States, 70121

Actively Recruiting

37

Maine VA Health Care System

Togus, Maine, United States, 04330

Actively Recruiting

38

Johns Hopkins University

Baltimore, Maryland, United States, 21287

Actively Recruiting

39

VA Boston Healthcare System

Boston, Massachusetts, United States, 002130

Actively Recruiting

40

VA Ann Arbor Healthcare System

Ann Arbor, Michigan, United States, 48105

Actively Recruiting

41

University of Michigan

Ann Arbor, Michigan, United States, 48109

Actively Recruiting

42

Essentia Health

Duluth, Minnesota, United States, 55805

Actively Recruiting

43

Allina Health

Minneapolis, Minnesota, United States, 55407

Active, Not Recruiting

44

Minneapolis VA Health Care System

Minneapolis, Minnesota, United States, 55417

Withdrawn

45

Mayo Clinic

Rochester, Minnesota, United States, 55905

Actively Recruiting

46

University of Mississippi Medical Center

Jackson, Mississippi, United States, 39216

Actively Recruiting

47

VA Medical Center Jackson

Jackson, Mississippi, United States, 39216

Actively Recruiting

48

University of Missouri Health System

Columbia, Missouri, United States, 65212

Actively Recruiting

49

St. Louis VA Medical Center

St Louis, Missouri, United States, 63106

Actively Recruiting

50

Washington University in St. Louis

St Louis, Missouri, United States, 63130

Actively Recruiting

51

University of Nebraska Medical Center

Omaha, Nebraska, United States, 67105

Actively Recruiting

52

Omaha VA Medical Center

Omaha, Nebraska, United States, 68105

Actively Recruiting

53

Reno VA/Sierra Nevada Health Care

Reno, Nevada, United States, 89502

Withdrawn

54

Northwell Health

Manhasset, New York, United States, 11030

Actively Recruiting

55

VA Hudson Valley Healthcare System

Montrose, New York, United States, 10548

Withdrawn

56

VA New York Harbor Healthcare System

New York, New York, United States, 10010

Not Yet Recruiting

57

Weill Cornell Medical College

New York, New York, United States, 10021

Actively Recruiting

58

Albert Einstein College of Medicine

The Bronx, New York, United States, 10461

Actively Recruiting

59

Bronx VA Medical Center

The Bronx, New York, United States, 10468

Withdrawn

60

Asheville VA-Charles George VA Medical Center

Asheville, North Carolina, United States, 28805

Actively Recruiting

61

University of North Carolina

Chapel Hill, North Carolina, United States, 27599

Actively Recruiting

62

Atrium Health

Charlotte, North Carolina, United States, 28207

Actively Recruiting

63

PREVENTABLE Tele-Site

Durham, North Carolina, United States, 27701

Actively Recruiting

64

Durham VA Medical Center

Durham, North Carolina, United States, 27705

Actively Recruiting

65

Duke University

Durham, North Carolina, United States, 27710

Actively Recruiting

66

Duke University - Kannapolis

Kannapolis, North Carolina, United States, 28081

Actively Recruiting

67

Wake Forest Baptist Hospital-Cardiology

Winston-Salem, North Carolina, United States, 27157

Actively Recruiting

68

Wake Forest Hospital - Geriatrics

Winston-Salem, North Carolina, United States, 27157

Actively Recruiting

69

Cincinnati VA Medical Center

Cincinnati, Ohio, United States, 45220

Actively Recruiting

70

Case Western Reserve University

Cleveland, Ohio, United States, 44106

Actively Recruiting

71

Ohio State University

Columbus, Ohio, United States, 43210

Actively Recruiting

72

Dayton VA Medical Center

Dayton, Ohio, United States, 45428

Actively Recruiting

73

Oregon Health and Science University

Portland, Oregon, United States, 97239

Not Yet Recruiting

74

Corporal Michael J. Crescenz VA Medical Center-Philadelphia VA

Philadelphia, Pennsylvania, United States, 19104

Withdrawn

75

Thomas Jefferson University

Philadelphia, Pennsylvania, United States, 19107

Not Yet Recruiting

76

University of Pittsburgh Medical Center

Pittsburgh, Pennsylvania, United States, 15213

Actively Recruiting

77

Providence VA Medical Center

Providence, Rhode Island, United States, 002908

Actively Recruiting

78

Charleston VA Medical Center

Charleston, South Carolina, United States, 29401

Actively Recruiting

79

Medical University of South Carolina

Charleston, South Carolina, United States, 29403

Actively Recruiting

80

Columbia VA Health Care/Dorn VA Medical Center

Columbia, South Carolina, United States, 29209

Actively Recruiting

81

VA Medical Center Memphis

Memphis, Tennessee, United States, 38104

Actively Recruiting

82

Meharry Medical College

Nashville, Tennessee, United States, 37208

Actively Recruiting

83

Nashville VA Medical Center

Nashville, Tennessee, United States, 37212

Actively Recruiting

84

Vanderbilt University Medical Center

Nashville, Tennessee, United States, 37212

Actively Recruiting

85

Baylor Scott and White Medical Center

Dallas, Texas, United States, 75210

Actively Recruiting

86

Dallas VA Medical Center

Dallas, Texas, United States, 75216

Actively Recruiting

87

University of Texas Southwestern Medical Center Dallas

Dallas, Texas, United States, 75390

Actively Recruiting

88

Doctors Hospital at Renaissance

Edinburg, Texas, United States, 78539

Actively Recruiting

89

University of Texas at Houston

Houston, Texas, United States, 77204

Actively Recruiting

90

San Antonio VA Medical Center

San Antonio, Texas, United States, 78229

Actively Recruiting

91

University of Texas Health Science Center at San Antonio

San Antonio, Texas, United States, 78229

Actively Recruiting

92

Intermountain

Murray, Utah, United States, 84107

Actively Recruiting

93

University of Utah

Salt Lake City, Utah, United States, 84132

Active, Not Recruiting

94

VA Salt Lake City Healthcare System

Salt Lake City, Utah, United States, 84148

Actively Recruiting

95

Richmond VA

Richmond, Virginia, United States, 23219

Actively Recruiting

96

Clarksburg VA Medical Center

Clarksburg, West Virginia, United States, 26301

Withdrawn

97

Mayo Clinic Health Systems - NW Wisconsin

Eau Claire, Wisconsin, United States, 54703

Actively Recruiting

98

Mayo Clinic Health System SW Wisconsin

La Crosse, Wisconsin, United States, 54601

Actively Recruiting

99

VA Madison Healthcare System

Madison, Wisconsin, United States, 53705

Actively Recruiting

100

Marshfield Clinic

Marshfield, Wisconsin, United States, 54449

Actively Recruiting

101

Medical College of Wisconsin

Milwaukee, Wisconsin, United States, 53295

Actively Recruiting

102

Milwaukee VA Medical Center

Milwaukee, Wisconsin, United States, 53295

Actively Recruiting

103

VA Carribbean Healthcare

San Juan, Puerto Rico, 00921

Actively Recruiting

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Research Team

P

Pamela Monds

CONTACT

B

Beth Harris

CONTACT

How is the study designed?

Study Type

INTERVENTIONAL

Masking

TRIPLE

Allocation

RANDOMIZED

Model

PARALLEL

Primary Purpose

PREVENTION

Number of Arms

2

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Pragmatic Evaluation of Events And Benefits of Lipid-lowering in Older Adults | DecenTrialz