Actively Recruiting
Predictive Accuracy of Platelet Lymphocyte Ratio & Platelet Neutrophil Ratio in Detecting Early Trauma Induced Coagulopathy
Led by Jubilee Mission Medical College and Research Institute · Updated on 2025-07-02
250
Participants Needed
1
Research Sites
4 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Trauma is a major cause of injury and death worldwide, often leading to significant health challenges. This research aims to evaluate how well the platelet-lymphocyte ratio (PLR) and platelet-neutrophil ratio (PNR) predict early trauma-induced coagulopathy (ETIC) in patients arriving at the emergency department (ED) within six hours of injury. These ratios reflect the balance between inflammation and immune response, which may help identify patients at risk early in their hospital stay. The study observes trauma patients who come to the ED and have blood tests ordered by their physician, specifically coagulation profiles. It focuses on measuring the PLR and PNR values upon admission, without administering any new treatments or interventions. The goal is to see how these markers predict outcomes such as the need for blood transfusions, prolonged ventilatory support, surgeries, and length of hospital stay during their admission. Participants will be monitored during their hospital stay, with researchers assessing laboratory results and clinical events such as transfusions, surgeries, and intensive care days. The main outcome is the accuracy of PLR and PNR in detecting ETIC within 24 hours. Secondary outcomes include comparing predictive values for transfusion needs, ventilatory support duration, emergent surgeries, and hospital stay length up to 30 days. The study is observational and does not involve additional treatments or procedures beyond usual care.
CONDITIONS
Brief Title
Predictive Accuracy of PLR and PNR in Detecting ETIC
Who Can Participate
Eligibility Criteria
You may qualify if you...
- All patients with trauma
- Presenting to emergency department within 6 hours of the injury event
- Coagulation profile ordered by the emergency department physician
You will not qualify if you...
- Received intravenous fluids, drugs, whole blood or blood products before hospital admission
- Injury from non-mechanical causes such as drowning, hanging, or burns
- Taking medications known to affect coagulation or blood counts
- Known chronic liver disease, chronic kidney failure, cancer, or blood disorders
- Not consenting to participate in the study
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Within 24 hours of hospital admission
Participants undergo blood tests to measure platelet lymphocyte ratio (PLR) and platelet neutrophil ratio (PNR) to help early risk stratification and prediction of trauma induced coagulopathy.
1 visit (in-person)
Duration - Up to 30 days or duration of hospital stay, whichever is earlier
Participants are monitored during their hospital stay or up to 30 days for outcomes including transfusion requirements, ventilatory support, surgeries, renal replacement therapy, and length of stay.
Follow-up assessments during hospital stay
Trial Site Locations
Total: 1 location
1
Jubilee Mission Medical College
Thrissur, Kerala, India, 670303
Actively Recruiting
Research Team
D
Dr Siju V Abraham, MBBS MD
D
Dr Amrutha T, MBBS
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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