Observational Registry Study of Acute Treatment and Long-Term Outcomes in Children with Infectious Meningitis in Brazil

What this Trial Is About

Researchers are conducting a prospective, multicenter observational clinical registry involving pediatric patients under 18 years old who have suspected acute infectious meningitis in about 20 public and private hospitals across Brazil. The study aims to collect real-world data on current clinical management, treatment, and both short- and long-term outcomes to help improve national care protocols. It focuses on gathering evidence about acute infectious meningitis caused by bacterial, viral, or fungal infections. During hospitalization, clinical and laboratory data will be collected, including timing and type of antibiotic therapy, corticosteroid use, vaccination status, and neurological complications. Follow-up visits will occur at 28, 90, and 180 days after enrollment to assess outcomes such as mortality, length of hospital stay, re-hospitalization rates, hearing loss, neurological sequelae, and access to specialized rehabilitation services. The study will observe how treatments align with guidelines and record adverse events. Participants will be monitored through hospital data collection during their stay and follow-up appointments after discharge. Evaluations include functional neurological outcomes using pediatric scales, assessments of motor and cerebrovascular complications, and recording serious adverse events. The primary outcomes measured are mortality, re-hospitalization, hospital stay duration, and sensorineural hearing loss at day 28. Secondary outcomes involve longer-term mortality, rehabilitation access, and functional declines up to 180 days. The study runs until February 2027, aiming to inform pediatric care and public health policies in Brazil.

Prospective Clinical Registry of Acute Treatment and Long-term Assessment of Children Meningitis