Actively Recruiting
Prospective Observational Cohort Study of Cardiac Structure and Function in Children and Adults With Osteogenesis Imperfecta
Led by Istituto Ortopedico Rizzoli · Updated on 2025-12-17
40
Participants Needed
1
Research Sites
337 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This prospective observational investigation will examine the incidence and progression of cardiologic findings in individuals with OI across different age groups. Cardiopulmonary complications are recognized as major contributors to morbidity and mortality in adults with OI, although life expectancy has significantly improved in recent years due to medical advancements. By systematically evaluating cardiovascular involvement in this population, the study aims to generate clinically relevant evidence to inform early cardiologic screening strategies and support the development of harmonized and targeted management approaches, ultimately improving clinical practice and the quality of life of individuals living with OI.
CONDITIONS
Official Title
Prospective Observational Cohort Study of Cardiac Structure and Function in Children and Adults With Osteogenesis Imperfecta
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Diagnosis of Osteogenesis Imperfecta according to the modified Sillence classification (Mortier et al., 2019)
- Attendance at genetic consultations at the Rare Skeletal Diseases Unit of the IRCCS Rizzoli Orthopaedic Institute
- Willingness to undergo clinical and instrumental assessments at the IRCCS Rizzoli Orthopaedic Institute
You will not qualify if you...
- Having an acute upper or lower respiratory tract infection at the time of assessment
- Cognitive impairment affecting cooperation and ability to complete examinations
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
IRCCS Istituto Ortopedico Rizzoli
Bologna, Emilia-Romagna, Italy, 40136
Actively Recruiting
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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