Actively Recruiting
Pubertal Blockade and Estradiol Effects on Cardiometabolic Health for Transitioning Youth
Led by University of Colorado, Denver · Updated on 2025-06-10
90
Participants Needed
1
Research Sites
284 weeks
Total Duration
On this page
Sponsors
U
University of Colorado, Denver
Lead Sponsor
N
National Heart, Lung, and Blood Institute (NHLBI)
Collaborating Sponsor
AI-Summary
What this Trial Is About
To evaluate the effect of estradiol with or without a prior gonadotropin releasing hormone analogue on insulin sensitivity and vascular function in transgender females compared to cisgender controls.
CONDITIONS
Official Title
Pubertal Blockade and Estradiol Effects on Cardiometabolic Health for Transitioning Youth
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Identify as a transgender female
- Age 13-16 years at the time of enrollment
- If on a gonadotropin releasing hormone analogue, more than 6 months exposure
- Plan to start estradiol clinically in less than 4 months
- Cisgender males and females ages 13-16 years
You will not qualify if you...
- Cognitive, psychiatric, or physical impairment preventing study procedure tolerance
- Use of antipsychotic medications
- History of type 1 or type 2 diabetes
- Polycystic ovarian syndrome (for cisgender females)
- Hypertension with resting blood pressure equal or above 140/90 mm/Hg
- Weight over 400 lbs
- Use of oral progesterone medications including combined oral contraceptives or etonogestrel implant
- Pregnancy (for cisgender females)
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Children's Hospital Colorado
Aurora, Colorado, United States, 80045
Actively Recruiting
Research Team
N
Natalie Nokoff, MD, MSCS
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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