Objective Grading of Intraocular Inflammation in Uveitis Using Optical Coherence Tomography

What this Trial Is About

Researchers are evaluating a new method using a high resolution imaging device called optical coherence tomography (OCT) to count and classify different types of cells and proteins involved in anterior uveitis, which is inflammation in the front part of the eye caused by various systemic diseases. The study aims to create an unbiased, standard way to measure and understand this eye condition. This observational study includes participants with different eye conditions and healthy controls to compare findings. Participants are divided into three groups: those with active inflammation from diseases like spondyloarthritis, juvenile idiopathic arthritis, herpes simplex virus uveitis, birdshot chorioretinitis, Behcet disease, sarcoidosis, or other types of uveitis; those with vitreous floaters and posterior vitreous detachment; and healthy individuals with no history of eye inflammation, vitreous detachment, or eye surgery. The study uses OCT imaging to assess these groups and gather detailed eye cell and protein data. During the study, participants undergo OCT imaging and related eye assessments on Day 1 to identify and measure anterior chamber cells, flare, keratic precipitates, vitreous cells, and vitreous haze. The study tracks these eye inflammation markers without any treatment intervention. Participants must be between 5 and 85 years old and able to maintain steady eye fixation during imaging. The study continues until December 2026, with all visits and evaluations documented for research purposes.

Quantification & Classification of Inflammatory Cells in Uveitis Using OCT