What is this study trying to find out about pelvic congestion syndrome?

This study is evaluating how much pain relief women experience after coil embolization of the gonadal veins for pelvic congestion syndrome. It also aims to identify clinical or imaging factors that predict who might respond well or poorly to treatment. The research is sponsored by the University of Kansas Medical Center to help improve understanding of this condition.

Who may be eligible for this pelvic congestion syndrome clinical trial?

Women aged 18 or older with a diagnosis of pelvic congestion syndrome based on clinical and imaging criteria may be eligible. Participants should not have other causes of vein problems like nutcracker syndrome or prior surgeries for PCS. Only females are eligible. Please review eligibility criteria for more details.

Is there any cost to participate in this pelvic congestion syndrome clinical trial?

Study-related care, including the procedure and all trial visits, is provided at no cost. However, personal travel expenses may vary and are not guaranteed to be covered. Participants should plan accordingly for any travel or accommodation costs.

Actively Recruiting

Age: 18Years +

FEMALE

ID03794466

Measuring Pain Relief After Gonadal Vein Embolization in Women with Pelvic Congestion Syndrome

Led by University of Kansas Medical Center · Updated on 2026-03-23

Participants Needed

Research Sites

52 weeks

Total Duration

AI-Summary

What this Trial Is About

Chronic pelvic pain affects nearly 40% of women during their lifetime, with pelvic congestion syndrome PCS responsible for up to 30% of these cases. PCS is caused by problems in the gonadal veins, leading to painful swelling in the pelvic veins. While medical treatments aim to reduce ovarian function and tighten the veins, they often provide limited and short-term relief. This research aims to measure how much pain relief patients experience after undergoing coil embolization of the gonadal veins and to identify factors that predict better or worse outcomes. Participants will have coil embolization of the gonadal veins, a procedure performed to block the veins causing the congestion. This study observes patients treated in the Interventional Radiology division between October 2018 and October 2019. The degree of pain relief will be assessed over time, focusing especially on changes from before the procedure to one year after. Women in the study will be assessed using the Pelvic Congestion Symptom Pain Scale at baseline and up to 360 days after the embolization. Researchers will monitor pain levels and analyze clinical or imaging characteristics that might predict treatment response. The total participation time covers one year post-procedure, during which pain and treatment outcomes will be carefully tracked.

CONDITIONS

Brief Title

Quantify the Degree of Pain Relief of Pelvic Congestion Syndrome Following Gonadal Vein Embolization

Who Can Participate

Age: 18Years +

FEMALE

Eligibility Criteria

You may qualify if you...

Female patients 18 years of age or older
Meet the clinical and imaging criteria for the diagnosis of PCS and have no contraindications to coil embolization of the gonadal veins
Patients treated with coil embolization of the gonadal veins in the Interventional Radiology division between October 1, 2018 to October 1, 2019

You will not qualify if you...

Patients less than 18 years of age
Patients with an underlying cause of pelvic congestion syndrome unrelated to venous congestion and insufficiency, including nutcracker syndrome or a mass causing compression of the gonadal veins
Patients who have received prior surgical therapy for PCS, including bilateral salpingo-oophorectomy, gonadal vein resection, or gonadal vein ligation

Your Study Journey

Screening

Duration - 2 to 4 weeks

Participants are screened for eligibility to participate in the trial.

Observational Monitoring

Duration - Up to 12 months after the procedure

Participants who have undergone gonadal vein embolization are observed to quantify pain relief over time using the Pelvic Congestion Symptom Pain Scale.